神经科学通报(英文版)2023，Vol.39Issue(4) ：631-644.DOI:10.1007/s12264-022-00982-y

Interaction Between Memory Load and Experimental Design on Brain Connectivity and Network Topology

Heming Zhang Xin Di Bart Rypma Hang Yang Chun Meng Bharat Biswal
神经科学通报(英文版)2023，Vol.39Issue(4) ：631-644.DOI:10.1007/s12264-022-00982-y
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  • 维普
  • 万方数据

Interaction Between Memory Load and Experimental Design on Brain Connectivity and Network Topology

Heming Zhang 1Xin Di 2Bart Rypma 3Hang Yang 1Chun Meng 1Bharat Biswal4
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作者信息

  • 1. The Clinical Hospital of Chengdu Brain Science Institute,MOE Key Laboratory for Neuroinformation,Center for Information in Medicine,School of Life Science and Technology,University of Electronic Science and Technology of China,Chengdu 611731,China
  • 2. Department of Biomedical Engineering,New Jersey Institute of Technology,Newark 07102,USA
  • 3. Department of Psychology,University of Texas at Dallas,Dallas 75390,USA
  • 4. The Clinical Hospital of Chengdu Brain Science Institute,MOE Key Laboratory for Neuroinformation,Center for Information in Medicine,School of Life Science and Technology,University of Electronic Science and Technology of China,Chengdu 611731,China;Department of Biomedical Engineering,New Jersey Institute of Technology,Newark 07102,USA
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Abstract

The conventional approach to investigating functional connectivity in the block-designed study usually concatenates task blocks or employs residuals of task activa-tion.While providing many insights into brain functions,the block design adds more manipulation in functional network analysis that may reduce the purity of the blood oxygenation level-dependent signal.Recent studies utilized one single long run for task trials of the same condition,the so-called continuous design,to investigate functional connectivity based on task functional magnetic resonance imaging.Con-tinuous brain activities associated with the single-task condi-tion can be directly utilized for task-related functional con-nectivity assessment,which has been examined for working memory,sensory,motor,and semantic task experiments in previous research.But it remains unclear how the block and continuous design influence the assessment of task-related functional connectivity networks.This study aimed to dis-entangle the separable effects of block/continuous design and working memory load on task-related functional con-nectivity networks,by using repeated-measures analysis of variance.Across 50 young healthy adults,behavioral results of accuracy and reaction time showed a significant main effect of design as well as interaction between design and load.Imaging results revealed that the cingulo-opercular,fronto-parietal,and default model networks were associated with not only task activation,but significant main effects of design and load as well as their interaction on intra-and inter-network functional connectivity and global network topology.Moreover,a significant behavior-brain associa-tion was identified for the continuous design.This work has extended the evidence that continuous design can be used to study task-related functional connectivity and subtle brain-behavioral relationships.

Key words

Working memory/Functional connectivity/Network topology/Block design/Continuous design/Memory load

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基金项目

all participants in the study.This work was supported by the National Natural Science Foundation of China(62071109)

all participants in the study.This work was supported by the National Natural Science Foundation of China(61871420)

Provincial Natural Science Foundation of Sichuan(2022NSFSC0504)

出版年

2023
神经科学通报(英文版)
中国科学院上海生命科学研究院

神经科学通报(英文版)

CSTPCDCSCD
影响因子：0.741
ISSN：1673-7067
参考文献量101
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