首页|A Spacetime Odyssey of Neural Progenitors to Generate Neuronal Diversity

A Spacetime Odyssey of Neural Progenitors to Generate Neuronal Diversity

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To understand how the nervous system develops from a small pool of progenitors during early embryonic development,it is fundamentally important to identify the diversity of neuronal subtypes,decode the origin of neuronal diversity,and uncover the principles governing neuronal specification across different regions.Recent single-cell analyses have systematically identified neuronal diversity at unprecedented scale and speed,leaving the deconstruc-tion of spatiotemporal mechanisms for generating neuronal diversity an imperative and paramount challenge.In this review,we highlight three distinct strategies deployed by neural progenitors to produce diverse neuronal subtypes,including predetermined,stochastic,and cascade diversify-ing models,and elaborate how these strategies are imple-mented in distinct regions such as the neocortex,spinal cord,retina,and hypothalamus.Importantly,the identity of neural progenitors is defined by their spatial position and temporal patterning factors,and each type of progenitor cell gives rise to distinguishable cohorts of neuronal sub-types.Microenvironmental cues,spontaneous activity,and connectional pattern further reshape and diversify the fate of unspecialized neurons in particular regions.The illumination of how neuronal diversity is generated will pave the way for producing specific brain organoids to model human disease and desired neuronal subtypes for cell therapy,as well as understanding the organization of functional neural circuits and the evolution of the nervous system.

Neuronal diversityNeural progenitorsSpatiotemporal patterningCascade diversifying model

Mengmeng Ge、Amirhossein Sheikhshahrokh、Xiang Shi、Yu-Hong Zhang、Zhiheng Xu、Qing-Feng Wu

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State Key Laboratory of Molecular Development Biology,Institute of Genetics and Developmental Biology,Chinese Academy of Sciences,Beijing 100101,China

University of Chinese Academy of Sciences,Beijing 100101,China

Center for Excellence in Brain Science and Intelligence Technology,Chinese Academy of Sciences,Beijing 100101,China

Beijing Children's Hospital,Capital Medical University,Beijing 100045,China

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National Key R&D Program of ChinaNational Key R&D Program of ChinaNational Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaStrategic Priority Research Program of Chinese Academy of SciencesHundred-Talent Program(Chinese Academy of Sciences)Beijing Municipal Science & Technology CommissionBeijing Municipal Science & Technology Commission

2019YFA08019002018YFA080110481891002320709723192100231771131XDB32020000Z210010Z181100001518001

2023

10.1007/s12264-022-00956-0

神经科学通报(英文版)
中国科学院上海生命科学研究院

神经科学通报(英文版)

CSTPCDCSCD
影响因子：0.741
ISSN：1673-7067
年,卷(期)：2023.39(4)
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