首页|Depression and Anxiety During the COVID-19 Pandemic:Epidemiology,Mechanism,and Treatment

Depression and Anxiety During the COVID-19 Pandemic:Epidemiology,Mechanism,and Treatment

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The Coronavirus Disease 2019(COVID-19)pandemic has had an adverse impact on the physical and mental health of the public worldwide.In addition to illness in patients with COVID-19,isolated people and the general population have experienced mental health problems due to social distancing policies,mandatory lockdown,and other psychosocial factors,and the prevalence of depression and anxiety significantly increased during the pandemic.The purpose of this review is to elucidate the epidemiology,contributing factors,and pathogenesis of depression and anxiety.during the pandemic.These findings indicate that physicians and psychiatrists should pay more attention to and identify those with a high risk for mental problems,such as females,younger people,unmarried people,and those with a low educational level.In addition,researchers should focus on identifying the neural and neuroimmune mecha-nisms involved in depression and anxiety,and assess the intestinal microbiome to identify effective biomarkers.We also provide an overview of various intervention methods,including pharmacological treatment,psychological therapy,and physiotherapy,to provide a reference for different popu-lations to guide the development of optimized intervention methods.

COVID-19AnxietyDepressionEpidemiologyMechanismIntervention

Chunyan Zhu、Ting Zhang、Qianqian Li、Xingui Chen、Kai Wang

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School of Mental Health and Psychological Sciences,Anhui Medical University,Hefei 230032,China

Anhui Province Key Laboratory of Cognition and Neuropsychiatric Disorders,Hefei 230032,China

Collaborative Innovation Center of Neuropsychiatric Disorders and Mental Health,Hefei 230032,China

Department of Psychiatry,The First Affiliated Hospital of Anhui Medical University,Hefei 230032,China

Department of Neurology,The First Affiliated Hospital of Anhui Medical University,Hefei 230032,China

Institute of Artificial Intelligence,Hefei Comprehensive National Science Center,Hefei 230032,China

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Tthe National Natural Science Foundation of China

82090034

2023

10.1007/s12264-022-00970-2

神经科学通报(英文版)
中国科学院上海生命科学研究院

神经科学通报(英文版)

CSTPCDCSCD
影响因子：0.741
ISSN：1673-7067
年,卷(期)：2023.39(4)
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