A Virtual Reality Platform for Context-Dependent Cognitive Research in Rodents

Xue-Tong Qu ¹Jin-Ni Wu ¹Yunqing Wen ²Long Chen ²Shi-Lei Lv ³Li Liu ³Li-Jie Zhan ²Tian-Yi Liu ⁴Hua He ⁴Yu Liu ³Chun Xu¹

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作者信息

1. Institute of Neuroscience,State Key Laboratory of Neuroscience,Center for Excellence in Brain Science and Intelligence Technology,Chinese Academy of Sciences,Shanghai 200031,China;University of the Chinese Academy of Sciences,Beijing 100049,China;Shanghai Center for Brain Science and Brain-Inspired Intelligence Technology,Shanghai 201210,China
2. Institute of Neuroscience,State Key Laboratory of Neuroscience,Center for Excellence in Brain Science and Intelligence Technology,Chinese Academy of Sciences,Shanghai 200031,China
3. Institute of Automation,Chinese Academy of Sciences,Beijing 100190,China
4. Department of Neurosurgery,Third Affiliated Hospital of Navy Military Medical University,Shanghai 200438,China
折叠

Abstract

Animal survival necessitates adaptive behav-iors in volatile environmental contexts.Virtual reality(VR)technology is instrumental to study the neural mechanisms underlying behaviors modulated by environmental con-text by simulating the real world with maximized control of contextual elements.Yet current VR tools for rodents have limited flexibility and performance(e.g.,frame rate)for context-dependent cognitive research.Here,we describe a high-performance VR platform with which to study con-textual behaviors immersed in editable virtual contexts.This platform was assembled from modular hardware and custom-written software with flexibility and upgradability.Using this platform,we trained mice to perform context-dependent cognitive tasks with rules ranging from discrim-ination to delayed-sample-to-match while recording from thousands of hippocampal place cells.By precise manipula-tions of context elements,we found that the context recogni-tion was intact with partial context elements,but impaired by exchanges of context elements.Collectively,our work establishes a configurable VR platform with which to inves-tigate context-dependent cognition with large-scale neural recording.

Key words

Virtual reality/Spatial context/Contextual behavior/Hippocampus/Place cell/Learning and memory/Ca 2+ imaging

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基金项目

National Science and Technology Innovation 2030 Major Program(2022ZD0205000)

National Key R&D Program of China()

Strategic Priority Research Program of the Chinese Academy of Sciences(XDB32010105)

Strategic Priority Research Program of the Chinese Academy of Sciences(XDBS01010100)

Shanghai Municipal science and Technology Major Project(2018SHZDZX05)

Lingang Lab(LG202104-01-08)

National Natural Science Foundation of China(31771180)

National Natural Science Foundation of China(91732106)

an International Collaborative Project of the Shanghai Science and Technology Committee(201978677)

出版年

2023

神经科学通报(英文版)

中国科学院上海生命科学研究院

神经科学通报(英文版)

CSTPCDCSCD

影响因子：0.741

ISSN：1673-7067

参考文献量21

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