A Virtual Reality Platform for Context-Dependent Cognitive Research in Rodents

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外文摘要：Animal survival necessitates adaptive behav-iors in volatile environmental contexts.Virtual reality(VR)technology is instrumental to study the neural mechanisms underlying behaviors modulated by environmental con-text by simulating the real world with maximized control of contextual elements.Yet current VR tools for rodents have limited flexibility and performance(e.g.,frame rate)for context-dependent cognitive research.Here,we describe a high-performance VR platform with which to study con-textual behaviors immersed in editable virtual contexts.This platform was assembled from modular hardware and custom-written software with flexibility and upgradability.Using this platform,we trained mice to perform context-dependent cognitive tasks with rules ranging from discrim-ination to delayed-sample-to-match while recording from thousands of hippocampal place cells.By precise manipula-tions of context elements,we found that the context recogni-tion was intact with partial context elements,but impaired by exchanges of context elements.Collectively,our work establishes a configurable VR platform with which to inves-tigate context-dependent cognition with large-scale neural recording.

外文关键词：

Virtual realitySpatial contextContextual behaviorHippocampusPlace cellLearning and memoryCa 2+ imaging

作者：

Xue-Tong Qu、Jin-Ni Wu、Yunqing Wen、Long Chen、Shi-Lei Lv、Li Liu、Li-Jie Zhan、Tian-Yi Liu、Hua He、Yu Liu、Chun Xu

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作者单位：

Institute of Neuroscience,State Key Laboratory of Neuroscience,Center for Excellence in Brain Science and Intelligence Technology,Chinese Academy of Sciences,Shanghai 200031,China

University of the Chinese Academy of Sciences,Beijing 100049,China

Shanghai Center for Brain Science and Brain-Inspired Intelligence Technology,Shanghai 201210,China

Institute of Automation,Chinese Academy of Sciences,Beijing 100190,China

Department of Neurosurgery,Third Affiliated Hospital of Navy Military Medical University,Shanghai 200438,China

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基金：

National Science and Technology Innovation 2030 Major ProgramNational Key R&D Program of ChinaStrategic Priority Research Program of the Chinese Academy of SciencesStrategic Priority Research Program of the Chinese Academy of SciencesShanghai Municipal science and Technology Major ProjectLingang LabNational Natural Science Foundation of ChinaNational Natural Science Foundation of Chinaan International Collaborative Project of the Shanghai Science and Technology Committee

项目编号：

2022ZD0205000XDB32010105XDBS010101002018SHZDZX05LG202104-01-083177118091732106201978677

出版年：

2023

DOI：

10.1007/s12264-022-00964-0

神经科学通报(英文版)

中国科学院上海生命科学研究院

神经科学通报(英文版)

CSTPCDCSCD

影响因子：0.741

ISSN：1673-7067

年,卷(期)：2023.39(5)

参考文献量21