首页|Direction Selectivity of TmY Neurites in Drosophila

Direction Selectivity of TmY Neurites in Drosophila

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The perception of motion is an important func-tion of vision.Neural wiring diagrams for extracting direc-tional information have been obtained by connectome recon-struction.Direction selectivity in Drosophila is thought to originate in T4/T5 neurons through integrating inputs with different temporal filtering properties.Through genetic screening based on synaptic distribution,we isolated a new type of TmY neuron,termed TmY-ds,that form recipro-cal synaptic connections with T4/T5 neurons.Its neurites responded to grating motion along the four cardinal direc-tions and showed a variety of direction selectivity.Intrigu-ingly,its direction selectivity originated from temporal filtering neurons rather than T4/T5.Genetic silencing and activation experiments showed that TmY-ds neurons are functionally upstream of T4/T5.Our results suggest that direction selectivity is generated in a tripartite circuit formed among these three neurons—temporal filtering,TmY-ds,and T4/T5 neurons,in which TmY-ds plays a role in the enhancement of direction selectivity in T4/T5 neurons.

Direction selectivityTmY-dsSynaptic connectionTwo-photon calcium imagingDrosophila

Yinyin Zhao、Shanshan Ke、Guo Cheng、Xiaohua Lv、Jin Chang、Wei Zhou

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Britton Chance Center for Biomedical Photonics,Wuhan National Laboratory for Optoelectronics-Huazhong University of Science and Technology,Wuhan 430074,China

National Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaFundamental Research Funds for the Central Universities/HUSTFundamental Research Funds for the Central Universities/HUSTDirector Fund of WNLO,and the China Postdoctoral Science Foundation

61890950318710272016YXMS0342014TS0152015T80788

2023

10.1007/s12264-022-00966-y

神经科学通报(英文版)
中国科学院上海生命科学研究院

神经科学通报(英文版)

CSTPCDCSCD
影响因子：0.741
ISSN：1673-7067
年,卷(期)：2023.39(5)
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