首页|An Anterior Cingulate Cortex-to-Midbrain Projection Controls Chronic Itch in Mice

An Anterior Cingulate Cortex-to-Midbrain Projection Controls Chronic Itch in Mice

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Itch is an unpleasant sensation that provokes the desire to scratch.While acute itch serves as a protec-tive system to warn the body of external irritating agents,chronic itch is a debilitating but poorly-treated clinical dis-ease leading to repetitive scratching and skin lesions.How-ever,the neural mechanisms underlying the pathophysiol-ogy of chronic itch remain mysterious.Here,we identified a cell type-dependent role of the anterior cingulate cortex(ACC)in controlling chronic itch-related excessive scratch-ing behaviors in mice.Moreover,we delineated a neural circuit originating from excitatory neurons of the ACC to the ventral tegmental area(VTA)that was critically involved in chronic itch.Furthermore,we demonstrate that the ACCĺVTA circuit also selectively modulated histaminergic acute itch.Finally,the ACC neurons were shown to predomi-nantly innervate the non-dopaminergic neurons of the VTA.Taken together,our findings uncover a cortex-midbrain cir-cuit for chronic itch-evoked scratching behaviors and shed novel insights on therapeutic intervention.

Anterior cingulate cortexChronic itchVentral tegmental areaChemogeneticsNeural circuit

Ting-Ting Zhang、Su-Shan Guo、Hui-Ying Wang、Qi Jing、Xin Yi、Zi-Han Hu、Xin-Ren Yu、Tian-Le Xu、Ming-Gang Liu、Xuan Zhao

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Department of Anesthesiology,Shanghai Tenth People's Hospital,School of Medicine,Tongji University,Shanghai 200072,China

Department of Anatomy and Physiology,Shanghai Jiao Tong University School of Medicine,Shanghai 200025,China

Center for Brain Science of Shanghai Children's Medical Center,Shanghai Jiao Tong University School of Medicine,Shanghai 200127,China

National Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaShanghai Natural Science FoundationShanghai Natural Science FoundationShanghai Municipal Science and Technology Major Projectinnovative research team of highlevel local universities in Shanghai

8187378781961128024321709948220136218ZR142480020ZR14300002018SHZDZX05

2023

10.1007/s12264-022-00996-6

神经科学通报(英文版)
中国科学院上海生命科学研究院

神经科学通报(英文版)

CSTPCDCSCD
影响因子：0.741
ISSN：1673-7067
年,卷(期)：2023.39(5)
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