首页|Corticostriatal Neurons in the Anterior Auditory Field Regulate Frequency Discrimination Behavior

Corticostriatal Neurons in the Anterior Auditory Field Regulate Frequency Discrimination Behavior

扫码查看
原文链接
  • 万方数据
  • 维普
The anterior auditory field(AAF)is a core region of the auditory cortex and plays a vital role in dis-crimination tasks.However,the role of the AAF corticos-triatal neurons in frequency discrimination remains unclear.Here,we used c-Fos staining,fiber photometry recording,and pharmacogenetic manipulation to investigate the func-tion of the AAF corticostriatal neurons in a frequency dis-crimination task.c-Fos staining and fiber photometry record-ing revealed that the activity of AAF pyramidal neurons was significantly elevated during the frequency discrimination task.Pharmacogenetic inhibition of AAF pyramidal neu-rons significantly impaired frequency discrimination.In addition,histological results revealed that AAF pyramidal neurons send strong projections to the striatum.Moreover,pharmacogenetic suppression of the striatal projections from pyramidal neurons in the AAF significantly disrupted the frequency discrimination.Collectively,our findings show that AAF pyramidal neurons,particularly the AAF-striatum projections,play a crucial role in frequency discrimination behavior.

Anterior auditory fieldCorticostriatal neuronFrequency discriminationAAF-striatum projection

Zhao-Qun Wang、Hui-Zhong Wen、Tian-Tian Luo、Peng-Hui Chen、Yan-Dong Zhao、Guang-Yan Wu、Ying Xiong

展开 >

Department of Neurobiology,Chongqing Key Laboratory of Neurobiology,Army Medical University,Chongqing 400038,China

Experimental Center of Basic Medicine,Army Medical University,Chongqing 400038,China

National Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaOpen Project of Chongqing Key Laboratory of NeurobiologyOpen Project of Chongqing Key Laboratory of NeurobiologyNatural Science Foundation of Chongqing

3187107532071015cqsjsw202103cqsjsw202101cstc2020jcyjmsxmX0391

2023

10.1007/s12264-022-01015-4

神经科学通报(英文版)
中国科学院上海生命科学研究院

神经科学通报(英文版)

CSTPCDCSCD
影响因子：0.741
ISSN：1673-7067
年,卷(期)：2023.39(6)
  • 34