Abstract
The anterior auditory field(AAF)is a core region of the auditory cortex and plays a vital role in dis-crimination tasks.However,the role of the AAF corticos-triatal neurons in frequency discrimination remains unclear.Here,we used c-Fos staining,fiber photometry recording,and pharmacogenetic manipulation to investigate the func-tion of the AAF corticostriatal neurons in a frequency dis-crimination task.c-Fos staining and fiber photometry record-ing revealed that the activity of AAF pyramidal neurons was significantly elevated during the frequency discrimination task.Pharmacogenetic inhibition of AAF pyramidal neu-rons significantly impaired frequency discrimination.In addition,histological results revealed that AAF pyramidal neurons send strong projections to the striatum.Moreover,pharmacogenetic suppression of the striatal projections from pyramidal neurons in the AAF significantly disrupted the frequency discrimination.Collectively,our findings show that AAF pyramidal neurons,particularly the AAF-striatum projections,play a crucial role in frequency discrimination behavior.
基金项目
National Natural Science Foundation of China(31871075)
National Natural Science Foundation of China(32071015)
Open Project of Chongqing Key Laboratory of Neurobiology(cqsjsw202103)
Open Project of Chongqing Key Laboratory of Neurobiology(cqsjsw202101)
Natural Science Foundation of Chongqing(cstc2020jcyjmsxmX0391)
维普
万方数据