首页|Hippocampus:Molecular,Cellular,and Circuit Features in Anxiety

Hippocampus:Molecular,Cellular,and Circuit Features in Anxiety

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Anxiety disorders are currently a major psychi-atric and social problem,the mechanisms of which have been only partially elucidated.The hippocampus serves as a major target of stress mediators and is closely related to anxiety modulation.Yet so far,its complex anatomy has been a challenge for research on the mechanisms of anxiety regulation.Recent advances in imaging,virus tracking,and optogenetics/chemogenetics have permitted elucidation of the activity,connectivity,and function of specific cell types within the hippocampus and its connected brain regions,providing mechanistic insights into the elaborate organiza-tion of the hippocampal circuitry underlying anxiety.Studies of hippocampal neurotransmitter systems,including gluta-matergic,GABAergic,cholinergic,dopaminergic,and sero-tonergic systems,have contributed to the interpretation of the underlying neural mechanisms of anxiety.Neuropeptides and neuroinflammatory factors are also involved in anxiety modulation.This review comprehensively summarizes the hippocampal mechanisms associated with anxiety modula-tion,based on molecular,cellular,and circuit properties,to provide tailored targets for future anxiety treatment.

AnxietyHippocampusExcitatory neuronsInterneuronsNeural circuit

Hu-Jiang Shi、Shuang Wang、Xin-Ping Wang、Rui-Xin Zhang、Li-Juan Zhu

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Key Laboratory of Developmental Genes and Human Diseases,MOE,Department of Histology and Embryology,School of Medicine,Southeast University,Nanjing 210009,China

Shanghai Mental Health Center,Shanghai Jiao Tong University School of Medicine,Shanghai 201108,China

National Natural Science Foundation of ChinaSix Talent Peaks Project of Jiangsu ProvinceShanghai Rising-Star Program"Zhong Ying Young Scholar"project of Cyrus Tang Foundation

31970951YY-00521QA1407900

2023

10.1007/s12264-023-01020-1

神经科学通报(英文版)
中国科学院上海生命科学研究院

神经科学通报(英文版)

CSTPCDCSCD
影响因子：0.741
ISSN：1673-7067
年,卷(期)：2023.39(6)
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