Abstract
Anxiety disorders are currently a major psychi-atric and social problem,the mechanisms of which have been only partially elucidated.The hippocampus serves as a major target of stress mediators and is closely related to anxiety modulation.Yet so far,its complex anatomy has been a challenge for research on the mechanisms of anxiety regulation.Recent advances in imaging,virus tracking,and optogenetics/chemogenetics have permitted elucidation of the activity,connectivity,and function of specific cell types within the hippocampus and its connected brain regions,providing mechanistic insights into the elaborate organiza-tion of the hippocampal circuitry underlying anxiety.Studies of hippocampal neurotransmitter systems,including gluta-matergic,GABAergic,cholinergic,dopaminergic,and sero-tonergic systems,have contributed to the interpretation of the underlying neural mechanisms of anxiety.Neuropeptides and neuroinflammatory factors are also involved in anxiety modulation.This review comprehensively summarizes the hippocampal mechanisms associated with anxiety modula-tion,based on molecular,cellular,and circuit properties,to provide tailored targets for future anxiety treatment.
基金项目
National Natural Science Foundation of China(31970951)
Six Talent Peaks Project of Jiangsu Province(YY-005)
Shanghai Rising-Star Program(21QA1407900)
"Zhong Ying Young Scholar"project of Cyrus Tang Foundation()
维普
万方数据