Abstract
In this study,we explored the neural mechanism underlying impaired stereopsis and possible functional plas-ticity after strabismus surgery.We enrolled 18 stereo-defi-cient patients with intermittent exotropia before and after surgery,along with 18 healthy controls.Functional magnetic resonance imaging data were collected when participants viewed three-dimensional stimuli.Compared with controls,preoperative patients showed hypoactivation in higher-level dorsal(visual and parietal)areas and ventral visual areas.Pre-and postoperative activation did not significantly dif-fer in patients overall;patients with improved stereopsis showed stronger postoperative activation than preoperative activation in the right V3A and left intraparietal sulcus.Worse stereopsis and fusional control were correlated with preoperative hypoactivation,suggesting that cortical deficits along the two streams might reflect impaired stereopsis in intermittent exotropia.The correlation between improved stereopsis and activation in the right V3A after surgery indi-cates that functional plasticity may underlie the improve-ment of stereopsis.Thus,additional postoperative strategies are needed to promote functional plasticity and enhance the recovery of stereopsis.
基金项目
National Natural Science Foundation of China(82271117)
National Natural Science Foundation of China(8201001029)
National Natural Science Foundation of China(81730025)
Shanghai 2022 Science and Technology Innovation Action Plan(22ZR1410200)
维普
万方数据