首页|Cortical Deficits are Correlated with Impaired Stereopsis in Patients with Strabismus

Cortical Deficits are Correlated with Impaired Stereopsis in Patients with Strabismus

扫码查看
原文链接
  • 万方数据
  • 维普
In this study,we explored the neural mechanism underlying impaired stereopsis and possible functional plas-ticity after strabismus surgery.We enrolled 18 stereo-defi-cient patients with intermittent exotropia before and after surgery,along with 18 healthy controls.Functional magnetic resonance imaging data were collected when participants viewed three-dimensional stimuli.Compared with controls,preoperative patients showed hypoactivation in higher-level dorsal(visual and parietal)areas and ventral visual areas.Pre-and postoperative activation did not significantly dif-fer in patients overall;patients with improved stereopsis showed stronger postoperative activation than preoperative activation in the right V3A and left intraparietal sulcus.Worse stereopsis and fusional control were correlated with preoperative hypoactivation,suggesting that cortical deficits along the two streams might reflect impaired stereopsis in intermittent exotropia.The correlation between improved stereopsis and activation in the right V3A after surgery indi-cates that functional plasticity may underlie the improve-ment of stereopsis.Thus,additional postoperative strategies are needed to promote functional plasticity and enhance the recovery of stereopsis.

StereopsisBinocular disparityFunctional magnetic resonance imagingStrabismusIntermittent exotropia

Sida Xi、Yulian Zhou、Jing Yao、Xinpei Ye、Peng Zhang、Wen Wen、Chen Zhao

展开 >

Department of Ophthalmology and Visual Science,Eye and ENT Hospital,Shanghai Medical College,Fudan University,Shanghai 200031,China

State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science,Institutes of Brain Science,Fudan University,Shanghai 200031,China

Key Laboratory of Myopia,Fudan University,Ministry of Health,Shanghai 200031,China

Shanghai Key Laboratory of Visual Impairment and Restoration,Fudan University,Shanghai 200031,China

Department of Radiology,Eye and ENT Hospital,Shanghai Medical College,Fudan University,Shanghai 200031,China

State Key Laboratory of Brain and Cognitive Science,Institute of Biophysics,Chinese Academy of Sciences,Beijing 100101,China

展开 >

National Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaShanghai 2022 Science and Technology Innovation Action Plan

8227111782010010298173002522ZR1410200

2023

10.1007/s12264-022-00987-7

神经科学通报(英文版)
中国科学院上海生命科学研究院

神经科学通报(英文版)

CSTPCDCSCD
影响因子：0.741
ISSN：1673-7067
年,卷(期)：2023.39(7)
  • 70