首页|Projection-Specific Heterogeneity of the Axon Initial Segment of Pyramidal Neurons in the Prelimbic Cortex

Projection-Specific Heterogeneity of the Axon Initial Segment of Pyramidal Neurons in the Prelimbic Cortex

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The axon initial segment(AIS)is a highly spe-cialized axonal compartment where the action potential is initiated.The heterogeneity of AISs has been suggested to occur between interneurons and pyramidal neurons(PyNs),which likely contributes to their unique spiking properties.However,whether the various characteristics of AISs can be linked to specific PyN subtypes remains unknown.Here,we report that in the prelimbic cortex(PL)of the mouse,two types of PyNs with axon projections either to the contralat-eral PL or to the ipsilateral basal lateral amygdala,possess distinct AIS properties reflected by morphology,ion chan-nel expression,action potential initiation,and axo-axonic synaptic inputs from chandelier cells.Furthermore,projec-tion-specific AIS diversity is more prominent in the superfi-cial layer than in the deep layer.Thus,our study reveals the cortical layer-and axon projection-specific heterogeneity of PyN AISs,which may endow the spiking of various PyN types with exquisite modulation.

Axon initial segmentPyramidal neuronsHeterogeneityChandelier cell

Ankang Hu、Rui Zhao、Baihui Ren、Yang Li、Jiangteng Lu、Yilin Tai

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The State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science,and the Institutes of Brain Science,Fudan University,Shanghai 200032,China

School of Clinical Medicine,Fudan University,Shanghai 200032,China

Department of Anatomy and Physiology,Shanghai Jiao Tong University School of Medicine,Shanghai 200025,China

Center for Brain Science of Shanghai Children's Medical Center,Shanghai Jiao Tong University School of Medicine,Shanghai 200127,China

Shanghai Research Center for Brain Science and Brain-Inspired Intelligence,Shanghai 201210,China

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National Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaShanghai Pujiang ProgramNatural Science Foundation of ShanghaiShanghai Municipal Science and Technology Major ProjectZJ LabShanghai Center for Brain Science and Brain-Inspired TechnologyFudan Undergraduate Research Opportunities Program

82071450319729033200068120PJ140100020ZR14057002018SHZDZX01Wangdao 20046

2023

10.1007/s12264-023-01038-5

神经科学通报(英文版)
中国科学院上海生命科学研究院

神经科学通报(英文版)

CSTPCDCSCD
影响因子：0.741
ISSN：1673-7067
年,卷(期)：2023.39(7)
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