Chromatin Remodeling Factor SMARCA5 is Essential for Hippocampal Memory Maintenance via Metabolic Pathways in Mice

Yu Qu ¹Nan Zhou ²Xia Zhang ³Yan Li ²Xu-Feng Xu⁴

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作者信息

1. Institute of Neuropsychiatric Diseases,Qingdao University,Qingdao 266001,China
2. Department of Urology,Qilu Hospital of Shandong University,Jinan 250012,China
3. Institute of Neuropsychiatric Diseases,Qingdao University,Qingdao 266001,China;University of Ottawa Institute of Mental Health Research at the Royal,Ottawa K1Z7K4,Canada;Department of Anesthesiology and Perioperative Medicine,Xijing Hospital,Fourth Military Medical University,Xi'an 710032,China;Key Laboratory of Modern Teaching Technology & College of Life Sciences,Shaanxi Normal University,Xi'an 710062,China
4. Institute of Neuropsychiatric Diseases,Qingdao University,Qingdao 266001,China;University of Ottawa Institute of Mental Health Research at the Royal,Ottawa K1Z7K4,Canada
折叠

Abstract

Gene transcription and new protein synthesis regulated by epigenetics play integral roles in the formation of new memories.However,as an important part of epi-genetics,the function of chromatin remodeling in learning and memory has been less studied.Here,we showed that SMARCA5(SWI/SNF related,matrix-associated,actin-dependent regulator of chromatin,subfamily A,member 5),a critical chromatin remodeler,was responsible for hip-pocampus-dependent memory maintenance and neurogen-esis.Using proteomics analysis,we found protein expres-sion changes in the hippocampal dentate gyrus(DG)after the knockdown of SMARCA5 during contextual fear con-ditioning(CFC)memory maintenance in mice.Moreover,SMARCA5 was revealed to participate in CFC memory maintenance via modulating the proteins of metabolic path-ways such as nucleoside diphosphate kinase-3(NME3)and aminoacylase 1(ACY1).This work is the first to describe the role of SMARCA5 in memory maintenance and to dem-onstrate the involvement of metabolic pathways regulated by SMARCA5 in learning and memory.

Key words

Epigenetic regulation/SMARCA5/Hippocampal memory/Chromatin remodeling/Metabolic pathway

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基金项目

Youth Program of the National Natural Science Foundation of China(32000788)

Shandong Province Natural Science Foundation(ZR2019 BC097)

Key Project from the National Natural Science Foundation of China(81830035)

Major program of National Natural Science Foundation of China(82090033)

Major Basic research program of Shandong Province Natural Science Foundation(ZR2019ZD35)

Major program of Technological innovation 2030"Brain science and braininspired research"(2021ZD0203002)

Shandong Taishan Scholar Award()

Fundamental Research Funds of Qingdao University()

出版年

2023

神经科学通报(英文版)

中国科学院上海生命科学研究院

神经科学通报(英文版)

CSTPCDCSCD

影响因子：0.741

ISSN：1673-7067

参考文献量46

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