首页|Chromatin Remodeling Factor SMARCA5 is Essential for Hippocampal Memory Maintenance via Metabolic Pathways in Mice

Chromatin Remodeling Factor SMARCA5 is Essential for Hippocampal Memory Maintenance via Metabolic Pathways in Mice

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Gene transcription and new protein synthesis regulated by epigenetics play integral roles in the formation of new memories.However,as an important part of epi-genetics,the function of chromatin remodeling in learning and memory has been less studied.Here,we showed that SMARCA5(SWI/SNF related,matrix-associated,actin-dependent regulator of chromatin,subfamily A,member 5),a critical chromatin remodeler,was responsible for hip-pocampus-dependent memory maintenance and neurogen-esis.Using proteomics analysis,we found protein expres-sion changes in the hippocampal dentate gyrus(DG)after the knockdown of SMARCA5 during contextual fear con-ditioning(CFC)memory maintenance in mice.Moreover,SMARCA5 was revealed to participate in CFC memory maintenance via modulating the proteins of metabolic path-ways such as nucleoside diphosphate kinase-3(NME3)and aminoacylase 1(ACY1).This work is the first to describe the role of SMARCA5 in memory maintenance and to dem-onstrate the involvement of metabolic pathways regulated by SMARCA5 in learning and memory.

Epigenetic regulationSMARCA5Hippocampal memoryChromatin remodelingMetabolic pathway

Yu Qu、Nan Zhou、Xia Zhang、Yan Li、Xu-Feng Xu

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Institute of Neuropsychiatric Diseases,Qingdao University,Qingdao 266001,China

Department of Urology,Qilu Hospital of Shandong University,Jinan 250012,China

University of Ottawa Institute of Mental Health Research at the Royal,Ottawa K1Z7K4,Canada

Department of Anesthesiology and Perioperative Medicine,Xijing Hospital,Fourth Military Medical University,Xi'an 710032,China

Key Laboratory of Modern Teaching Technology & College of Life Sciences,Shaanxi Normal University,Xi'an 710062,China

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Youth Program of the National Natural Science Foundation of ChinaShandong Province Natural Science FoundationKey Project from the National Natural Science Foundation of ChinaMajor program of National Natural Science Foundation of ChinaMajor Basic research program of Shandong Province Natural Science FoundationMajor program of Technological innovation 2030"Brain science and braininspired research"Shandong Taishan Scholar AwardFundamental Research Funds of Qingdao University

32000788ZR2019 BC0978183003582090033ZR2019ZD352021ZD0203002

2023

10.1007/s12264-023-01032-x

神经科学通报(英文版)
中国科学院上海生命科学研究院

神经科学通报(英文版)

CSTPCDCSCD
影响因子：0.741
ISSN：1673-7067
年,卷(期)：2023.39(7)
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