首页|Role of the Voltage-Gated Proton Channel Hv1 in Nervous Systems

Role of the Voltage-Gated Proton Channel Hv1 in Nervous Systems

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Hv1 is the only voltage-gated proton-selective channel in mammalian cells.It contains a conserved volt-age-sensor domain,shared by a large class of voltage-gated ion channels,but lacks a pore domain.Its primary role is to extrude protons from the cytoplasm upon pH reduction and membrane depolarization.The best-known function of Hv1 is the regulation of cytosolic pH and the nicotinamide adenine dinucleotide phosphate oxidase-dependent produc-tion of reactive oxygen species.Accumulating evidence indicates that Hv1 is expressed in nervous systems,in addi-tion to immune cells and others.Here,we summarize the molecular properties,distribution,and physiological func-tions of Hv1 in the peripheral and central nervous systems.We describe the recently discovered functions of Hv1 in various neurological diseases,including brain or spinal cord injury,ischemic stroke,demyelinating diseases,and pain.We also summarize the current advances in the discovery and application of Hv1-targeted small molecules in neuro-logical diseases.Finally,we discuss the current limitations of our understanding of Hv1 and suggest future research directions.

Voltage-gated ion channelHv1ProtonROSNeuroinflammationNeurological diseasesPain

Yu Shen、Yuncheng Luo、Ping Liao、Yunxia Zuo、Ruotian Jiang

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Department of Anesthesiology,West China Hospital,Sichuan University,Chengdu 610000,China

Laboratory of Anesthesia and Critical Care Medicine,National-Local Joint Engineering Research Center of Translational Medicine of Anesthesiology,Department of Anesthesiology,West China Hospital,Sichuan University,Chengdu 610000,China

National Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaNational Natural Science Foundation of China1-3-5 Project for Disciplines of Excellence of West China Hospital of Sichuan University

320710038227124981873808ZYJC21034

2023

10.1007/s12264-023-01053-6

神经科学通报(英文版)
中国科学院上海生命科学研究院

神经科学通报(英文版)

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影响因子：0.741
ISSN：1673-7067
年,卷(期)：2023.39(7)
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