神经科学通报(英文版)2023,Vol.39Issue(8) :1193-1209.DOI:10.1007/s12264-022-01008-3

Circuit-Specific Control of Blood Pressure by PNMT-Expressing Nucleus Tractus Solitarii Neurons

Shirui Jun Xianhong Ou Luo Shi Hongxiao Yu Tianjiao Deng Jinting Chen Xiaojun Nie Yinchao Hao Yishuo Shi Wei Liu Yanming Tian Sheng Wang Fang Yuan
神经科学通报(英文版)2023,Vol.39Issue(8) :1193-1209.DOI:10.1007/s12264-022-01008-3

Circuit-Specific Control of Blood Pressure by PNMT-Expressing Nucleus Tractus Solitarii Neurons

Shirui Jun 1Xianhong Ou 2Luo Shi 1Hongxiao Yu 1Tianjiao Deng 1Jinting Chen 3Xiaojun Nie 1Yinchao Hao 1Yishuo Shi 1Wei Liu 1Yanming Tian 1Sheng Wang 4Fang Yuan4
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作者信息

  • 1. Department of Neurobiology,Hebei Medical University,Shijiazhuang 050017,China
  • 2. Institute of Cardiovascular Research,Southwest Medical University,Luzhou 646000,China
  • 3. Core Facilities and Centers,Institute of Medicine and Health,Hebei Medical University,Shijiazhuang 050017,China
  • 4. Department of Neurobiology,Hebei Medical University,Shijiazhuang 050017,China;Hebei Key Laboratory of Neurophysiology,Shijiazhuang 050017,China
  • 折叠

Abstract

The nucleus tractus solitarii(NTS)is one of the morphologically and functionally defined centers that engage in the autonomic regulation of cardiovascular activ-ity.Phenotypically-characterized NTS neurons have been implicated in the differential regulation of blood pressure(BP).Here,we investigated whether phenylethanolamine N-methyltransferase(PNMT)-expressing NTS(NTSPNMT)neurons contribute to the control of BP.We demonstrate that photostimulation of NTSPNMT neurons has variable effects on BP.A depressor response was produced during optogenetic stimulation of NTSPNMT neurons projecting to the paraventricular nucleus of the hypothalamus,lateral parabrachial nucleus,and caudal ventrolateral medulla.Con-versely,photostimulation of NTSPNMT neurons projecting to the rostral ventrolateral medulla produced a robust pressor response and bradycardia.In addition,genetic ablation of both NTSPNMT neurons and those projecting to the rostral ventrolateral medulla impaired the arterial baroreflex.Over-all,we revealed the neuronal phenotype-and circuit-specific mechanisms underlying the contribution of NTSPNMT neu-rons to the regulation of BP.

Key words

Nucleus tractus solitarii/Blood pressure/Rostral ventrolateral medulla/Optogenetics/Neural circuit

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基金项目

Core Facilities and Centers,Institute of Medicine and Health,Hebei Medical University for technical support()

Natural Science Foundation of China(31971050)

Natural Science Foundation of Hebei Province for Distinguished Young Scholars(H2020206509)

Hebei Province Innovative Research Project for Postgraduate(2021074)

Natural Science Foundation of Hebei Province for Innovative Research Group Project(H2021206203)

出版年

2023
神经科学通报(英文版)
中国科学院上海生命科学研究院

神经科学通报(英文版)

CSTPCDCSCD
影响因子:0.741
ISSN:1673-7067
参考文献量58
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