Circuit-Specific Control of Blood Pressure by PNMT-Expressing Nucleus Tractus Solitarii Neurons

Shirui Jun ¹Xianhong Ou ²Luo Shi ¹Hongxiao Yu ¹Tianjiao Deng ¹Jinting Chen ³Xiaojun Nie ¹Yinchao Hao ¹Yishuo Shi ¹Wei Liu ¹Yanming Tian ¹Sheng Wang ⁴Fang Yuan⁴

扫码查看

作者信息

1. Department of Neurobiology,Hebei Medical University,Shijiazhuang 050017,China
2. Institute of Cardiovascular Research,Southwest Medical University,Luzhou 646000,China
3. Core Facilities and Centers,Institute of Medicine and Health,Hebei Medical University,Shijiazhuang 050017,China
4. Department of Neurobiology,Hebei Medical University,Shijiazhuang 050017,China;Hebei Key Laboratory of Neurophysiology,Shijiazhuang 050017,China
折叠

Abstract

The nucleus tractus solitarii(NTS)is one of the morphologically and functionally defined centers that engage in the autonomic regulation of cardiovascular activ-ity.Phenotypically-characterized NTS neurons have been implicated in the differential regulation of blood pressure(BP).Here,we investigated whether phenylethanolamine N-methyltransferase(PNMT)-expressing NTS(NTSPNMT)neurons contribute to the control of BP.We demonstrate that photostimulation of NTSPNMT neurons has variable effects on BP.A depressor response was produced during optogenetic stimulation of NTSPNMT neurons projecting to the paraventricular nucleus of the hypothalamus,lateral parabrachial nucleus,and caudal ventrolateral medulla.Con-versely,photostimulation of NTSPNMT neurons projecting to the rostral ventrolateral medulla produced a robust pressor response and bradycardia.In addition,genetic ablation of both NTSPNMT neurons and those projecting to the rostral ventrolateral medulla impaired the arterial baroreflex.Over-all,we revealed the neuronal phenotype-and circuit-specific mechanisms underlying the contribution of NTSPNMT neu-rons to the regulation of BP.

Key words

Nucleus tractus solitarii/Blood pressure/Rostral ventrolateral medulla/Optogenetics/Neural circuit

引用本文复制引用

基金项目

Core Facilities and Centers,Institute of Medicine and Health,Hebei Medical University for technical support()

Natural Science Foundation of China(31971050)

Natural Science Foundation of Hebei Province for Distinguished Young Scholars(H2020206509)

Hebei Province Innovative Research Project for Postgraduate(2021074)

Natural Science Foundation of Hebei Province for Innovative Research Group Project(H2021206203)

出版年

2023

神经科学通报(英文版)

中国科学院上海生命科学研究院

神经科学通报(英文版)

CSTPCDCSCD

影响因子：0.741

ISSN：1673-7067

参考文献量58

段落导航