首页|Circuit-Specific Control of Blood Pressure by PNMT-Expressing Nucleus Tractus Solitarii Neurons

Circuit-Specific Control of Blood Pressure by PNMT-Expressing Nucleus Tractus Solitarii Neurons

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The nucleus tractus solitarii(NTS)is one of the morphologically and functionally defined centers that engage in the autonomic regulation of cardiovascular activ-ity.Phenotypically-characterized NTS neurons have been implicated in the differential regulation of blood pressure(BP).Here,we investigated whether phenylethanolamine N-methyltransferase(PNMT)-expressing NTS(NTSPNMT)neurons contribute to the control of BP.We demonstrate that photostimulation of NTSPNMT neurons has variable effects on BP.A depressor response was produced during optogenetic stimulation of NTSPNMT neurons projecting to the paraventricular nucleus of the hypothalamus,lateral parabrachial nucleus,and caudal ventrolateral medulla.Con-versely,photostimulation of NTSPNMT neurons projecting to the rostral ventrolateral medulla produced a robust pressor response and bradycardia.In addition,genetic ablation of both NTSPNMT neurons and those projecting to the rostral ventrolateral medulla impaired the arterial baroreflex.Over-all,we revealed the neuronal phenotype-and circuit-specific mechanisms underlying the contribution of NTSPNMT neu-rons to the regulation of BP.

Nucleus tractus solitariiBlood pressureRostral ventrolateral medullaOptogeneticsNeural circuit

Shirui Jun、Xianhong Ou、Luo Shi、Hongxiao Yu、Tianjiao Deng、Jinting Chen、Xiaojun Nie、Yinchao Hao、Yishuo Shi、Wei Liu、Yanming Tian、Sheng Wang、Fang Yuan

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Department of Neurobiology,Hebei Medical University,Shijiazhuang 050017,China

Institute of Cardiovascular Research,Southwest Medical University,Luzhou 646000,China

Core Facilities and Centers,Institute of Medicine and Health,Hebei Medical University,Shijiazhuang 050017,China

Hebei Key Laboratory of Neurophysiology,Shijiazhuang 050017,China

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Core Facilities and Centers,Institute of Medicine and Health,Hebei Medical University for technical supportNatural Science Foundation of ChinaNatural Science Foundation of Hebei Province for Distinguished Young ScholarsHebei Province Innovative Research Project for PostgraduateNatural Science Foundation of Hebei Province for Innovative Research Group Project

31971050H20202065092021074H2021206203

2023

10.1007/s12264-022-01008-3

神经科学通报(英文版)
中国科学院上海生命科学研究院

神经科学通报(英文版)

CSTPCDCSCD
影响因子：0.741
ISSN：1673-7067
年,卷(期)：2023.39(8)
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