首页|Targeting Peripheral μ-opioid Receptors or μ-opioid Receptor-Expressing Neurons Does not Prevent Morphine-induced Mechanical Allodynia and Anti-allodynic Tolerance

Targeting Peripheral μ-opioid Receptors or μ-opioid Receptor-Expressing Neurons Does not Prevent Morphine-induced Mechanical Allodynia and Anti-allodynic Tolerance

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The chronic use of morphine and other opioids is associated with opioid-induced hypersensitivity(OIH)and analgesic tolerance.Among the different forms of OIH and tolerance,the opioid receptors and cell types mediat-ing opioid-induced mechanical allodynia and anti-allo-dynic tolerance remain unresolved.Here we demonstrated that the loss of peripheral μ-opioid receptors(MORs)or MOR-expressing neurons attenuated thermal tolerance,but did not affect the expression and maintenance of morphine-induced mechanical allodynia and anti-allodynic tolerance.To confirm this result,we made dorsal root ganglia-dorsal roots-sagittal spinal cord slice preparations and recorded low-threshold Aβ-fiber stimulation-evoked inputs and out-puts in superficial dorsal horn neurons.Consistent with the behavioral results,peripheral MOR loss did not prevent the opening of Aβ mechanical allodynia pathways in the spinal dorsal horn.Therefore,the peripheral MOR signaling path-way may not be an optimal target for preventing mechanical OIH and analgesic tolerance.Future studies should focus more on central mechanisms.

μ-opioid receptorMorphineMechanical allodyniaPunctate allodyniaDynamic allodyniaOIHToleranceAβ-fiber

Feng Du、Guangjuan Yin、Lei Han、Xi Liu、Dong Dong、Kaifang Duan、Jiantao Huo、Yanyan Sun、Longzhen Cheng

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School of Life Science and Technology,Harbin Institute of Technology,Harbin 150001,China

Shenzhen Key Laboratory of Gene Regulation and Systems Biology,School of Life Sciences,Southern University of Science and Technology,Shenzhen 518055,China

Department of Biology,Brain Research Center,Southern University of Science and Technology,Shenzhen 518055,China

Department of Anesthesiology,Shenzhen University General Hospital,Shenzhen University,Shenzhen 518055,China

Department of Biology,School of Life Sciences,Southern University of Science and Technology,Shenzhen 518055,China

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Ministry of Science and Technology of ChinaNational Natural Science Foundation of ChinaShenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research InstitutionsGuangdong Science and Technology CommitteeGuangdong Science and Technology CommitteeShenzhen Innovation Committee of Science and TechnologyNatural Science Foundation of Shenzhen University General HospitalBasic Research Project of Shenzhen Science and Technology Innovation Commission

2021ZD0203302321709962021SHIBS00022019A1515010041A2021319ZDSYS20200811144002008SUGH2018QD024JCYJ20210324100206017

2023

10.1007/s12264-022-01009-2

神经科学通报(英文版)
中国科学院上海生命科学研究院

神经科学通报(英文版)

CSTPCDCSCD
影响因子：0.741
ISSN：1673-7067
年,卷(期)：2023.39(8)
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