首页|Microglial Depletion does not Affect the Laterality of Mechanical Allodynia in Mice

Microglial Depletion does not Affect the Laterality of Mechanical Allodynia in Mice

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Mechanical allodynia(MA),including punctate and dynamic forms,is a common and debilitating symptom suffered by millions of chronic pain patients.Some periph-eral injuries result in the development of bilateral MA,while most injuries usually led to unilateral MA.To date,the con-trol of such laterality remains poorly understood.Here,to study the role of microglia in the control of MA laterality,we used genetic strategies to deplete microglia and tested both dynamic and punctate forms of MA in mice.Surpris-ingly,the depletion of central microglia did not prevent the induction of bilateral dynamic and punctate MA.Moreo-ver,in dorsal root ganglion-dorsal root-sagittal spinal cord slice preparations we recorded the low-threshold Aβ-fiber stimulation-evoked inputs and outputs of superficial dorsal horn neurons.Consistent with behavioral results,microglial depletion did not prevent the opening of bilateral gates for Aβ pathways in the superficial dorsal horn.This study chal-lenges the role of microglia in the control of MA lateral-ity in mice.Future studies are needed to further understand whether the role of microglia in the control of MA laterality is etiology-or species-specific.

MicrogliaMechanical allodyniaLateralitySpinal dorsal hornAβDynamic allodyniaPunctate allodynia

Quan Ma、Dongmei Su、Jiantao Huo、Guangjuan Yin、Dong Dong、Kaifang Duan、Hong Cheng、Huiling Xu、Jiao Ma、Dong Liu、Bin Mou、Jiyun Peng、Longzhen Cheng

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School of Life Science and Technology,Harbin Institute of Technology,Harbin 150001,China

Shenzhen Key Laboratory of Gene Regulation and Systems Biology,School of Life Sciences,Southern University of Science and Technology,Shenzhen 518055,China

Department of Biology,Brain Research Center,Southern University of Science and Technology,Shenzhen 518055,China

Institute of Life Science,Nanchang University,Nanchang 330031,China

Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research Institutions,Shenzhen 518055,China

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Cheng laboratory for their support and discussionsMinistry of Science and Technology of ChinaNational Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaShenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research InstitutionsGuangdong Science and Technology CommitteeGuangdong Science and Technology CommitteeShenzhen Innovation Committee of Science and TechnologyShenzhen Science and Technology Innovation Committee

2021ZD020330232170996320601992021SHIBS00022019A1515010041A2021319ZDSYS20200811144002008JCYJ20180302174233348

2023

10.1007/s12264-022-01017-2

神经科学通报(英文版)
中国科学院上海生命科学研究院

神经科学通报(英文版)

CSTPCDCSCD
影响因子：0.741
ISSN：1673-7067
年,卷(期)：2023.39(8)
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