Lipocalin 2 in the Paraventricular Thalamic Nucleus Contributes to DSS-Induced Depressive-Like Behaviors

Yeru Chen ¹Du Zheng ¹Hongwei Wang ¹Shuxia Zhang ¹Youfa Zhou ¹Xinlong Ke ¹Gang Chen¹

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作者信息

1. Department of Anesthesiology,Sir Run Run Shaw Hospital,School of Medicine,Zhejiang University,Hangzhou 310016,China
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Abstract

The incidence rate of anxiety and depression is significantly higher in patients with inflammatory bowel dis-eases(IBD)than in the general population.The mechanisms underlying dextran sulfate sodium(DSS)-induced depres-sive-like behaviors are still unclear.We clarified that IBD mice induced by repeated administration of DSS presented depressive-like behaviors.The paraventricular thalamic nucleus(PVT)was regarded as the activated brain region by the number of c-fos-labeled neurons.RNA-sequencing analysis showed that lipocalin 2(Lcn2)was upregulated in the PVT of mice with DSS-induced depressive behaviors.Upregulating Lcn2 from neuronal activity induced den-dritic spine loss and the secreted protein induced chemokine expression and subsequently contributed to microglial acti-vation leading to blood-brain barrier permeability.Moreo-ver,Lcn2 silencing in the PVT alleviated the DSS-induced depressive-like behaviors.The present study demonstrated that elevated Lcn2 in the PVT is a critical factor for DSS-induced depressive behaviors.

Key words

Inflammatory bowel disease/Depression/Lcn2/Blood-brain barrier

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基金项目

Core Facilities,Zhejiang University School of Medicine()

National Natural Science Foundation of China(82001424)

National Natural Science Foundation of China(82171176)

Key Program of the Natural Science Foundation of Zhejiang,China(LZ19H090003)

出版年

2023

神经科学通报(英文版)

中国科学院上海生命科学研究院

神经科学通报(英文版)

CSTPCDCSCD

影响因子：0.741

ISSN：1673-7067

参考文献量53

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