Physiological Roles of β-amyloid in Regulating Synaptic Function:Implications for AD Pathophysiology

Wenwen Cai ¹Linxi Li ²Shaoming Sang ¹Xiaoli Pan ¹Chunjiu Zhong³

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作者信息

1. Department of Neurology,Zhongshan Hospital,Fudan University,Shanghai 200032,China
2. Basic Medical College,Nanchang University,Nanchang 330031,China
3. Department of Neurology,Zhongshan Hospital,Fudan University,Shanghai 200032,China;State Key Laboratory of Medical Neurobiology,Institutes of Brain Science & Collaborative Innovation Center for Brain Science,Fudan University,Shanghai 200032,China
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Abstract

The physiological functions of endogenous amyloid-β(Aβ),which plays important role in the pathol-ogy of Alzheimer's disease(AD),have not been paid enough attention.Here,we review the multiple physiological effects of Aβ,particularly in regulating synaptic transmission,and the possible mechanisms,in order to decipher the real char-acters of Aβ under both physiological and pathological con-ditions.Some worthy studies have shown that the depriva-tion of endogenous Aβ gives rise to synaptic dysfunction and cognitive deficiency,while the moderate elevation of this peptide enhances long term potentiation and leads to neuronal hyperexcitability.In this review,we provide a new view for understanding the role of Aβ in AD pathophysiol-ogy from the perspective of physiological meaning.

Key words

Aβ/Physiological role/Synapse/LTP/Synaptic vesicle cycle/Cognition/AD

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基金项目

Shanghai Municipal Science and Technology Major Project()

National Key Research and Development Program Foundation of China(2016YFC1306403)

National Natural Science Foundation of China(81870822)

National Natural Science Foundation of China(91332201)

National Natural Science Foundation of China(81901081)

National Natural Science Foundation of China(81600930)

National Natural Science Foundation of China(82171408)

National Natural Science Foundation of China(82171411)

Natural Science Foundation of Fujian Province(2020CXB049)

出版年

2023

神经科学通报(英文版)

中国科学院上海生命科学研究院

神经科学通报(英文版)

CSTPCDCSCD

影响因子：0.741

ISSN：1673-7067

参考文献量250

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