Abstract
Females increase aggression for mating oppor-tunities and for acquiring reproductive resources.Although the close relationship between female aggression and mat-ing status is widely appreciated,whether and how female aggression is regulated by mating-related cues remains poorly understood.Here we report an interesting observa-tion that Drosophila virgin females initiate high-frequency attacks toward mated females.We identify 11-cis-vacce-nyl acetate(cVA),a male-derived pheromone transferred to females during mating,which promotes virgin female aggression.We subsequently reveal a cVA-responsive neural circuit consisting of four orders of neurons,including Or67d,DA1,aSP-g,and pC1 neurons,that mediate cVA-induced virgin female aggression.We also determine that aSP-g neurons release acetylcholine(ACh)to excite pC1 neurons via the nicotinic ACh receptor nAChRα7.Together,beyond revealing cVA as a mating-related inducer of virgin female aggression,our results identify a neural circuit linking the chemosensory perception of mating-related cues to aggres-sive behavior in Drosophila females.
基金项目
National Natural Science Foundation of China(31872280)
National Natural Science Foundation of China(31622054)
Strategic Priority Research Program of the Chinese Academy of Science(XDB11010800)
China Postdoctoral science Foundation(E290D51135)
Chinese Academy of sciences(E129Q21105)
维普
万方数据