A Neural Circuit Controlling Virgin Female Aggression Induced by Mating-related Cues in Drosophila

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外文摘要：Females increase aggression for mating oppor-tunities and for acquiring reproductive resources.Although the close relationship between female aggression and mat-ing status is widely appreciated,whether and how female aggression is regulated by mating-related cues remains poorly understood.Here we report an interesting observa-tion that Drosophila virgin females initiate high-frequency attacks toward mated females.We identify 11-cis-vacce-nyl acetate(cVA),a male-derived pheromone transferred to females during mating,which promotes virgin female aggression.We subsequently reveal a cVA-responsive neural circuit consisting of four orders of neurons,including Or67d,DA1,aSP-g,and pC1 neurons,that mediate cVA-induced virgin female aggression.We also determine that aSP-g neurons release acetylcholine(ACh)to excite pC1 neurons via the nicotinic ACh receptor nAChRα7.Together,beyond revealing cVA as a mating-related inducer of virgin female aggression,our results identify a neural circuit linking the chemosensory perception of mating-related cues to aggres-sive behavior in Drosophila females.

外文关键词：

DrosophilaAggressionPheromone11-cis-vaccenyl acetateAcetylcholineNeural circuit

作者：

Xiaolu Wan、Peng Shen、Kai Shi、Jing Li、Fengming Wu、Chuan Zhou

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作者单位：

State Key Laboratory of Integrated Management of Pest Insects and Rodents,Institute of Zoology,Chinese Academy of Sciences,Beijing 100101,China

University of Chinese Academy of Sciences,Beijing 100049,China

Institute of Molecular Physiology,Shenzhen Bay Laboratory,Shenzhen 518132,China

基金：

National Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaStrategic Priority Research Program of the Chinese Academy of ScienceChina Postdoctoral science FoundationChinese Academy of sciences

项目编号：

3187228031622054XDB11010800E290D51135E129Q21105

出版年：

2023

DOI：

10.1007/s12264-023-01050-9

神经科学通报(英文版)

中国科学院上海生命科学研究院

神经科学通报(英文版)

CSTPCDCSCD

影响因子：0.741

ISSN：1673-7067

年,卷(期)：2023.39(9)

参考文献量74