首页|nNOS and Neurological,Neuropsychiatric Disorders:A 20-Year Story
nNOS and Neurological,Neuropsychiatric Disorders:A 20-Year Story
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In the central nervous system,nitric oxide(NO),a free gas with multitudinous bioactivities,is mainly pro-duced from the oxidation of L-arginine by neuronal nitric oxide synthase(nNOS).In the past 20 years,the studies in our group and other laboratories have suggested a signifi-cant involvement of nNOS in a variety of neurological and neuropsychiatric disorders.In particular,the interactions between the PDZ domain of nNOS and its adaptor proteins,including post-synaptic density 95,the carboxy-terminal PDZ ligand of nNOS,and the serotonin transporter,signifi-cantly influence the subcellular localization and functions of nNOS in the brain.The nNOS-mediated protein-protein interactions provide new attractive targets and guide the dis-covery of therapeutic drugs for neurological and neuropsy-chiatric disorders.Here,we summarize the work on the roles of nNOS and its association with multiple adaptor proteins on neurological and neuropsychiatric disorders.
nNOSnNOS-PSD95nNOS-CAPONnNOS-SERTNeurological and neuropsychiatric disorder
Li-Juan Zhu、Fei Li、Dong-Ya Zhu
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Key Laboratory of Developmental Genes and Human Diseases,Ministry of Education,Department of Histology and Embryology,School of Medicine,Southeast University,Nanjing 210009,China
Department of Medicinal Chemistry,School of Pharmacy,Nanjing Medical University,Nanjing 211166,China
Department of Pharmacology,School of Pharmacy,Nanjing Medical University,Nanjing 211166,China
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