Compound from Magnolia officinalis Ameliorates White Matter Injury by Promoting Oligodendrocyte Maturation in Chronic Cerebral Ischemia Models

Zhi Zhang ¹Xin Shu ¹Qian Cao ¹Lushan Xu ¹Zibu Wang ¹Chenggang Li ¹Shengnan Xia ²Pengfei Shao ²Xinyu Bao ²Liang Sun ¹Yuhao Xu ²Yun Xu³

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作者信息

1. Department of Neurology,Nanjing Drum Tower Hospital Clinical College of Traditional Chinese and Western Medicine,Nanjing University of Chinese Medicine,Nanjing 210008,China;Department of Neurology,Nanjing Drum Tower Hospital,Affiliated Hospital of Medical School and State Key Laboratory of Pharmaceutical Biotechnology and Institute of Translational Medicine for Brain Critical Diseases,Nanjing University,Nanjing 210008,China
2. Department of Neurology,Nanjing Drum Tower Hospital,Affiliated Hospital of Medical School and State Key Laboratory of Pharmaceutical Biotechnology and Institute of Translational Medicine for Brain Critical Diseases,Nanjing University,Nanjing 210008,China;Jiangsu Key Laboratory for Molecular Medicine,Medical School of Nanjing University,Nanjing 210008,China
3. Department of Neurology,Nanjing Drum Tower Hospital Clinical College of Traditional Chinese and Western Medicine,Nanjing University of Chinese Medicine,Nanjing 210008,China;Department of Neurology,Nanjing Drum Tower Hospital,Affiliated Hospital of Medical School and State Key Laboratory of Pharmaceutical Biotechnology and Institute of Translational Medicine for Brain Critical Diseases,Nanjing University,Nanjing 210008,China;Jiangsu Key Laboratory for Molecular Medicine,Medical School of Nanjing University,N
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Abstract

Chronic cerebral hypoperfusion leads to white matter injury(WMI),which subsequently causes neurode-generation and even cognitive impairment.However,due to the lack of treatment specifically for WMI,novel recognized and effective therapeutic strategies are urgently needed.In this study,we found that honokiol and magnolol,two com-pounds derived from Magnolia officinalis,significantly facilitated the differentiation of primary oligodendrocyte precursor cells(OPCs)into mature oligodendrocytes,with a more prominent effect of the former compound.Moreover,our results demonstrated that honokiol treatment improved myelin injury,induced mature oligodendrocyte protein expression,attenuated cognitive decline,promoted oligoden-drocyte regeneration,and inhibited astrocytic activation in the bilateral carotid artery stenosis model.Mechanistically,honokiol increased the phosphorylation of serine/threonine kinase(Akt)and mammalian target of rapamycin(mTOR)by activating cannabinoid receptor 1 during OPC differentia-tion.Collectively,our study indicates that honokiol might serve as a potential treatment for WMI in chronic cerebral ischemia.

Key words

Honokiol/White matter injury/Oligodendrocyte/Vascular dementia

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基金项目

National Natural Science Foundation of China(81920108017)

National Natural Science Foundation of China(82130036)

Key Research and Development Program of Jiangsu Province of China(BE2020620)

Jiangsu Province Key Medical Discipline(ZDXKA2016020)

出版年

2023

神经科学通报(英文版)

中国科学院上海生命科学研究院

神经科学通报(英文版)

CSTPCDCSCD

影响因子：0.741

ISSN：1673-7067

参考文献量1

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