Reproducible Abnormalities and Diagnostic Generalizability of White Matter in Alzheimer's Disease

Yida Qu ¹Pan Wang ²Hongxiang Yao ²Dawei Wang ³Chengyuan Song ⁴Hongwei Yang ⁵Zengqiang Zhang ⁶Pindong Chen ¹Xiaopeng Kang ¹Kai Du ¹Lingzhong Fan ¹Bo Zhou ⁷Tong Han ⁸Chunshui Yu ⁹Xi Zhang ⁷Nianming Zuo ¹Tianzi Jiang ¹Yuying Zhou ²Bing Liu ¹⁰Ying Han ¹¹Jie Lu ⁵Yong Liu ¹²Multi-Center Alzheimer's Disease Imaging(MCADI)Consortium

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作者信息

1. Brainnetome Center and National Laboratory of Pattern Recognition,Institute of Automation,Chinese Academy of Sciences,Beijing 100190,China;School of Artificial Intelligence,University of Chinese Academy of Sciences,Beijing 100049,China
2. Department of Neurology,Tianjin Huanhu Hospital,Tianjin University,Tianjin 300222,China
3. Department of Radiology,Department of Epidemiology and Health Statistics,School of Public Health,Qilu Hospital of Shandong University,Ji'nan 250063,China
4. Department of Neurology,Qilu Hospital of Shandong University,Ji'nan 250063,China
5. Department of Radiology,Xuanwu Hospital of Capital Medical University,Beijing 100053,China
6. Branch of Chinese,PLA General Hospital,Sanya 572022,China
7. Department of Neurology,The Second Medical Centre,National Clinical Research Centre for Geriatric Diseases,Chinese PLA General Hospital,Beijing 100089,China
8. Department of Radiology,Tianjin Huanhu Hospital,Tianjin 300222,China
9. Department of Radiology,Tianjin Medical University General Hospital,Tianjin 300052,China
10. Brainnetome Center and National Laboratory of Pattern Recognition,Institute of Automation,Chinese Academy of Sciences,Beijing 100190,China;School of Artificial Intelligence,University of Chinese Academy of Sciences,Beijing 100049,China;State Key Lab of Cognition Neuroscience&Learning,Beijing Normal University,Beijing 100091,China
11. Department of Neurology,Xuanwu Hospital of Capital Medical University,Beijing 100053,China;Beijing Institute of Geriatrics,Beijing 100053,China;National Clinical Research Center for Geriatric Disorders,Beijing 100053,China;Center of Alzheimer's Disease,Beijing Institute for Brain Disorders,Beijing 100053,China
12. Brainnetome Center and National Laboratory of Pattern Recognition,Institute of Automation,Chinese Academy of Sciences,Beijing 100190,China;School of Artificial Intelligence,Beijing University of Posts and Telecommunications,Beijing 100876,China
折叠

Abstract

Alzheimer's disease(AD)is associated with the impairment of white matter(WM)tracts.The current study aimed to verify the utility of WM as the neuroim-aging marker of AD with multisite diffusion tensor imag-ing datasets[321 patients with AD,265 patients with mild cognitive impairment(MCI),279 normal controls(NC)],a unified pipeline,and independent site cross-validation.Automated fiber quantification was used to extract diffu-sion profiles along tracts.Random-effects meta-analyses showed a reproducible degeneration pattern in which frac-tional anisotropy significantly decreased in the AD and MCI groups compared with NC.Machine learning models using tract-based features showed good generalizability among independent site cross-validation.The diffusion metrics of the altered regions and the AD probability predicted by the models were highly correlated with cognitive ability in the AD and MCI groups.We highlighted the reproducibility and generalizability of the degeneration pattern of WM tracts in AD.

Key words

Alzheimer's disease/Diffusion tensor imaging/White matter tracts/Cross-validation

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基金项目

Science and Technology Innovation 2030 Major Projects(2022ZD0211600)

Beijing Natural Science Funds for Distinguished Young Scholars(JQ20036)

Beijing Nova Program(20220484177)

Fundamental Research Funds for the Central Universities(2021XD-A03)

National Natural Science Foundation of China(82172018)

National Natural Science Foundation of China(81871438)

National Natural Science Foundation of China(61633018)

National Natural Science Foundation of China(81571062)

National Natural Science Foundation of China(81400890)

National Natural Science Foundation of China(81471120)

National Natural Science Foundation of China(81701781)

出版年

2023

神经科学通报(英文版)

中国科学院上海生命科学研究院

神经科学通报(英文版)

CSTPCDCSCD

影响因子：0.741

ISSN：1673-7067

参考文献量69

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