首页|The Secondary Motor Cortex-striatum Circuit Contributes to Suppressing Inappropriate Responses in Perceptual Decision Behavior

The Secondary Motor Cortex-striatum Circuit Contributes to Suppressing Inappropriate Responses in Perceptual Decision Behavior

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The secondary motor cortex(M2)encodes choice-related information and plays an important role in cue-guided actions.M2 neurons innervate the dorsal stria-tum(DS),which also contributes to decision-making behav-ior,yet how M2 modulates signals in the DS to influence perceptual decision-making is unclear.Using mice perform-ing a visual Go/No-Go task,we showed that inactivating M2 projections to the DS impaired performance by increasing the false alarm(FA)rate to the reward-irrelevant No-Go stimulus.The choice signal of M2 neurons correlated with behavioral performance,and the inactivation of M2 neurons projecting to the DS reduced the choice signal in the DS.By measuring and manipulating the responses of direct or indirect pathway striatal neurons defined by M2 inputs,we found that the indirect pathway neurons exhibited a shorter response latency to the No-Go stimulus,and inactivating their early responses increased the FA rate.These results demonstrate that the M2-to-DS pathway is crucial for sup-pressing inappropriate responses in perceptual decision behavior.

Secondary motor cortexStriatumVisual perceptual decisionChoice signalDirect and indirect pathway striatal neurons

Jing Liu、Dechen Liu、Xiaotian Pu、Kexin Zou、Taorong Xie、Yaping Li、Haishan Yao

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Institute of Neuroscience,State Key Laboratory of Neuroscience,CAS Center for Excellence in Brain Science and Intelligence Technology,Chinese Academy of Sciences,Shanghai 200031,China

University of Chinese Academy of Sciences,Beijing 100049,China

Shanghai Center for Brain Science and Brain-Inspired Intelligence Technology,Shanghai 201210,China

STI2030-Major ProjectsNational Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaLingang LabShanghai Municipal Science and Technology Major ProjectStrategic Priority Research Program of the Chinese Academy of Sciences

2021ZD0203700/2021ZD0203703317711513217103032100829LG202104-01-032018SHZDZX05XDB32010200

2023

10.1007/s12264-023-01073-2

神经科学通报(英文版)
中国科学院上海生命科学研究院

神经科学通报(英文版)

CSTPCDCSCD
影响因子：0.741
ISSN：1673-7067
年,卷(期)：2023.39(10)
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