The Secondary Motor Cortex-striatum Circuit Contributes to Suppressing Inappropriate Responses in Perceptual Decision Behavior

Jing Liu ¹Dechen Liu ²Xiaotian Pu ¹Kexin Zou ¹Taorong Xie ²Yaping Li ²Haishan Yao³

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作者信息

1. Institute of Neuroscience,State Key Laboratory of Neuroscience,CAS Center for Excellence in Brain Science and Intelligence Technology,Chinese Academy of Sciences,Shanghai 200031,China;University of Chinese Academy of Sciences,Beijing 100049,China
2. Institute of Neuroscience,State Key Laboratory of Neuroscience,CAS Center for Excellence in Brain Science and Intelligence Technology,Chinese Academy of Sciences,Shanghai 200031,China
3. Institute of Neuroscience,State Key Laboratory of Neuroscience,CAS Center for Excellence in Brain Science and Intelligence Technology,Chinese Academy of Sciences,Shanghai 200031,China;Shanghai Center for Brain Science and Brain-Inspired Intelligence Technology,Shanghai 201210,China
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Abstract

The secondary motor cortex(M2)encodes choice-related information and plays an important role in cue-guided actions.M2 neurons innervate the dorsal stria-tum(DS),which also contributes to decision-making behav-ior,yet how M2 modulates signals in the DS to influence perceptual decision-making is unclear.Using mice perform-ing a visual Go/No-Go task,we showed that inactivating M2 projections to the DS impaired performance by increasing the false alarm(FA)rate to the reward-irrelevant No-Go stimulus.The choice signal of M2 neurons correlated with behavioral performance,and the inactivation of M2 neurons projecting to the DS reduced the choice signal in the DS.By measuring and manipulating the responses of direct or indirect pathway striatal neurons defined by M2 inputs,we found that the indirect pathway neurons exhibited a shorter response latency to the No-Go stimulus,and inactivating their early responses increased the FA rate.These results demonstrate that the M2-to-DS pathway is crucial for sup-pressing inappropriate responses in perceptual decision behavior.

Key words

Secondary motor cortex/Striatum/Visual perceptual decision/Choice signal/Direct and indirect pathway striatal neurons

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基金项目

STI2030-Major Projects(2021ZD0203700/2021ZD0203703)

National Natural Science Foundation of China(31771151)

National Natural Science Foundation of China(32171030)

National Natural Science Foundation of China(32100829)

Lingang Lab(LG202104-01-03)

Shanghai Municipal Science and Technology Major Project(2018SHZDZX05)

Strategic Priority Research Program of the Chinese Academy of Sciences(XDB32010200)

出版年

2023

神经科学通报(英文版)

中国科学院上海生命科学研究院

神经科学通报(英文版)

CSTPCDCSCD

影响因子：0.741

ISSN：1673-7067

参考文献量100

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