首页|Genetic Approaches for Neural Circuits Dissection in Non-human Primates
Genetic Approaches for Neural Circuits Dissection in Non-human Primates
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Genetic tools,which can be used for the mor-phology study of specific neurons,pathway-selective con-nectome mapping,neuronal activity monitoring,and manip-ulation with a spatiotemporal resolution,have been widely applied to the understanding of complex neural circuit formation,interactions,and functions in rodents.Recently,similar genetic approaches have been tried in non-human primates(NHPs)in neuroscience studies for dissecting the neural circuits involved in sophisticated behaviors and clini-cal brain disorders,although they are still very preliminary.In this review,we introduce the progress made in the devel-opment and application of genetic tools for brain studies on NHPs.We also discuss the advantages and limitations of each approach and provide a perspective for using genetic tools to study the neural circuits of NHPs.
Genetic toolNeural circuitNon-human primate
Ling Li、Zhen Liu
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Institute of Neuroscience,CAS Center for Excellence in Brain Science and Intelligence Technology,CAS Key Laboratory of Primate Neurobiology,State Key Laboratory of Neuroscience,Chinese Academy of Sciences,Shanghai 200031,China
University of Chinese Academy of Sciences,Beijing 100049,China
Shanghai Center for Brain Science and Brain-Inspired Intelligence Technology,Shanghai 200031,China
Shanghai Municipal Science and Technology Major ProjectStrategic Priority Research Program of the Chinese Academy of SciencesLingang National Laboratory Key Project
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