Abstract
Autism spectrum disorder(ASD)is one of the common neurodevelopmental disorders in children.Its etiol-ogy and pathogenesis are poorly understood.Previous stud-ies have suggested potential changes in the complement and coagulation pathways in individuals with ASD.In this study,using multiple reactions monitoring proteomic technology,16 of the 33 proteins involved in this pathway were identi-fied as differentially-expressed proteins in plasma between children with ASD and controls.Among them,CFHR3,C4BPB,C4BPA,CFH,C9,SERPIND1,C8A,F9,and F11 were found to be altered in the plasma of children with ASD for the first time.SERPIND1 expression was positively cor-related with the CARS score.Using the machine learning method,we obtained a panel composed of 12 differentially-expressed proteins with diagnostic potential for ASD.We also reviewed the proteins changed in this pathway in the brain and blood of patients with ASD.The complement and coagulation pathways may be activated in the periph-eral blood of children with ASD and play a key role in the pathogenesis of ASD.
基金项目
National Natural Science Foundation of China(31870825)
Shenzhen Bureau of Science,Technology,and Information(JCYJ20170412110026229)
Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research Institutions(2022SHIBS0003)
2019 Guiyang Science and Technology Bureau()
Guiyang First People's Hospital,Great Health Science and Technology Cooperation Project()
Instrument Analysis Center of Shenzhen University()
维普
万方数据