首页|A Systematic Investigation of Complement and Coagulation-Related Protein in Autism Spectrum Disorder Using Multiple Reaction Monitoring Technology

A Systematic Investigation of Complement and Coagulation-Related Protein in Autism Spectrum Disorder Using Multiple Reaction Monitoring Technology

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Autism spectrum disorder(ASD)is one of the common neurodevelopmental disorders in children.Its etiol-ogy and pathogenesis are poorly understood.Previous stud-ies have suggested potential changes in the complement and coagulation pathways in individuals with ASD.In this study,using multiple reactions monitoring proteomic technology,16 of the 33 proteins involved in this pathway were identi-fied as differentially-expressed proteins in plasma between children with ASD and controls.Among them,CFHR3,C4BPB,C4BPA,CFH,C9,SERPIND1,C8A,F9,and F11 were found to be altered in the plasma of children with ASD for the first time.SERPIND1 expression was positively cor-related with the CARS score.Using the machine learning method,we obtained a panel composed of 12 differentially-expressed proteins with diagnostic potential for ASD.We also reviewed the proteins changed in this pathway in the brain and blood of patients with ASD.The complement and coagulation pathways may be activated in the periph-eral blood of children with ASD and play a key role in the pathogenesis of ASD.

Autism spectrum disorderBiomarkerComplement and coagulation cascadeComplement systemMachine learningMultiple reaction monitoring

Xueshan Cao、Xiaoxiao Tang、Chengyun Feng、Jing Lin、Huajie Zhang、Qiong Liu、Qihong Zheng、Hongbin Zhuang、Xukun Liu、Haiying Li、Naseer Ullah Khan、Liming Shen

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College of Life Science and Oceanography,Shenzhen University,Shenzhen 518060,China

College of Physics and Optoelectronics Engineering,Shenzhen University,Shenzhen 518060,China

Maternal and Child Health Hospital of Baoan,Shenzhen 518100,China

Department of Endocrinology,Guiyang First People's Hospital,Guiyang 550002,China

Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research Institutions,Shenzhen 518055,China

Shenzhen Key Laboratory of Marine Biotechnology and Ecology,Shenzhen 518060,China

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National Natural Science Foundation of ChinaShenzhen Bureau of Science,Technology,and InformationShenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research Institutions2019 Guiyang Science and Technology BureauGuiyang First People's Hospital,Great Health Science and Technology Cooperation ProjectInstrument Analysis Center of Shenzhen University

31870825JCYJ201704121100262292022SHIBS0003

2023

10.1007/s12264-023-01055-4

神经科学通报(英文版)
中国科学院上海生命科学研究院

神经科学通报(英文版)

CSTPCDCSCD
影响因子：0.741
ISSN：1673-7067
年,卷(期)：2023.39(11)
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