首页|Genetic Architecture and Functional Implications of the CSF-Contacting Nucleus
Genetic Architecture and Functional Implications of the CSF-Contacting Nucleus
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We previously identified a unique nucleus,the cerebrospinal fluid(CSF)-contacting nucleus.This study aims to understand its gene architecture and preliminarily suggest its functions.The results showed that there were about 19,666 genes in this nucleus,of which 913 were dis-tinct from the dorsal raphe nucleus(non-CSF contacting).The top 40 highly-expressed genes are mainly related to energy metabolism,protein synthesis,transport,secretion,and hydrolysis.The main neurotransmitter is 5-HT.The receptors of 5-HT and GABA are abundant.The channels for Cl-,Na+,K+,and Ca2+ are routinely expressed.The signal-ing molecules associated with the CaMK,JAK,and MAPK pathways were identified accurately.In particular,the chan-nels of transient receptor potential associated with nocicep-tors and the solute carrier superfamily members associated with cell membrane transport were significantly expressed.The relationship between the main genes of the nucleus and life activities is preliminarily verified.
Gene architectureCerebrospinal fluid-contacting nucleus(CSF-contacting nucleus)Biological function
Jiangsu Province Key Laboratory of Anesthesiology,Xuzhou Medical University,Xuzhou 221004,China
Jiangsu Province Key Laboratory of Anesthesia and Analgesia Application Technology,Xuzhou Medical University,Xuzhou 221004,China
NMPA Key Laboratory for Research and Evaluation of Narcotic and Psychotropic Drugs,Xuzhou 221008,China
School of Nursing,Xuzhou Medical University,Xuzhou 221004,China
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National Natural Science Foundation of China2021 Original Exploration Program recommended by expertsNatural Science Foundation of Jiangsu ProvinceChinese Postdoctoral science Foundation
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