神经科学通报(英文版)2023，Vol.39Issue(11) ：1638-1654.DOI:10.1007/s12264-023-01084-z

Genetic Architecture and Functional Implications of the CSF-Contacting Nucleus

Siyuan Song Yumin Yuan Lingling Xu Jun Jiang Ying Li Yao Yan Qing Li Fang Zhou Junli Cao Licai Zhang
神经科学通报(英文版)2023，Vol.39Issue(11) ：1638-1654.DOI:10.1007/s12264-023-01084-z
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Genetic Architecture and Functional Implications of the CSF-Contacting Nucleus

Siyuan Song 1Yumin Yuan 1Lingling Xu 1Jun Jiang 1Ying Li 1Yao Yan 1Qing Li 2Fang Zhou 2Junli Cao 1Licai Zhang1
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作者信息

  • 1. Jiangsu Province Key Laboratory of Anesthesiology,Xuzhou Medical University,Xuzhou 221004,China;Jiangsu Province Key Laboratory of Anesthesia and Analgesia Application Technology,Xuzhou Medical University,Xuzhou 221004,China;NMPA Key Laboratory for Research and Evaluation of Narcotic and Psychotropic Drugs,Xuzhou 221008,China
  • 2. Jiangsu Province Key Laboratory of Anesthesiology,Xuzhou Medical University,Xuzhou 221004,China;Jiangsu Province Key Laboratory of Anesthesia and Analgesia Application Technology,Xuzhou Medical University,Xuzhou 221004,China;NMPA Key Laboratory for Research and Evaluation of Narcotic and Psychotropic Drugs,Xuzhou 221008,China;School of Nursing,Xuzhou Medical University,Xuzhou 221004,China
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Abstract

We previously identified a unique nucleus,the cerebrospinal fluid(CSF)-contacting nucleus.This study aims to understand its gene architecture and preliminarily suggest its functions.The results showed that there were about 19,666 genes in this nucleus,of which 913 were dis-tinct from the dorsal raphe nucleus(non-CSF contacting).The top 40 highly-expressed genes are mainly related to energy metabolism,protein synthesis,transport,secretion,and hydrolysis.The main neurotransmitter is 5-HT.The receptors of 5-HT and GABA are abundant.The channels for Cl-,Na+,K+,and Ca2+ are routinely expressed.The signal-ing molecules associated with the CaMK,JAK,and MAPK pathways were identified accurately.In particular,the chan-nels of transient receptor potential associated with nocicep-tors and the solute carrier superfamily members associated with cell membrane transport were significantly expressed.The relationship between the main genes of the nucleus and life activities is preliminarily verified.

Key words

Gene architecture/Cerebrospinal fluid-contacting nucleus(CSF-contacting nucleus)/Biological function

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基金项目

National Natural Science Foundation of China()

2021 Original Exploration Program recommended by experts(82150007)

Natural Science Foundation of Jiangsu Province(BK20190987)

Chinese Postdoctoral science Foundation(2018M642328)

出版年

2023
神经科学通报(英文版)
中国科学院上海生命科学研究院

神经科学通报(英文版)

CSTPCDCSCD
影响因子：0.741
ISSN：1673-7067
参考文献量54
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