Spatial Distribution of Parvalbumin-Positive Fibers in the Mouse Brain and Their Alterations in Mouse Models of Temporal Lobe Epilepsy and Parkinson's Disease

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外文摘要：Parvalbumin interneurons belong to the major types of GABAergic interneurons.Although the distribu-tion and pathological alterations of parvalbumin interneu-ron somata have been widely studied,the distribution and vulnerability of the neurites and fibers extending from par-valbumin interneurons have not been detailly interrogated.Through the Cre recombinase-reporter system,we visual-ized parvalbumin-positive fibers and thoroughly investigated their spatial distribution in the mouse brain.We found that parvalbumin fibers are widely distributed in the brain with specific morphological characteristics in different regions,among which the cortex and thalamus exhibited the most intense parvalbumin signals.In regions such as the stria-tum and optic tract,even long-range thick parvalbumin pro-jections were detected.Furthermore,in mouse models of temporal lobe epilepsy and Parkinson's disease,parvalbu-min fibers suffered both massive and subtle morphological alterations.Our study provides an overview of parvalbumin fibers in the brain and emphasizes the potential pathological implications of parvalbumin fiber alterations.

外文关键词：

Parvalbumin interneuronNeuronal fiberSpatial distributionPathological alterationTemporal lobe epilepsyStatus epilepticusParkinson's disease

作者：

Changgeng Song、Yan Zhao、Jiajia Zhang、Ziyi Dong、Xin Kang、Yuqi Pan、Jinle Du、Yiting Gao、Haifeng Zhang、Ye Xi、Hui Ding、Fang Kuang、Wenting Wang、Ceng Luo、Zhengping Zhang、Qinpeng Zhao、Jiazhou Yang、Wen Jiang、Shengxi Wu、Fang Gao

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作者单位：

Department of Neurobiology and Institute of Neurosciences,School of Basic Medicine,Fourth Military Medical University,Xi'an 710032,China

Department of Neurology,Xijing Hospital,Fourth Military Medical University,Xi'an 710032,China

National Translational Science Center for Molecular Medicine,Department of Cell Biology,Fourth Military Medical University,Xi'an 710032,China

Department of Spinal Surgery,Honghui Hospital,Xi'an Jiaotong University College of Medicine,Xi'an 710054,China

The Medical College of Yan'an University,Yan'an 716000,China

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基金：

Ministry of science and Technology of ChinaNational Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaKey R&D Program of Shaanxi Province

项目编号：

2021ZD020100582071529819742042021SF-238

出版年：

2023

DOI：

10.1007/s12264-023-01083-0

神经科学通报(英文版)

中国科学院上海生命科学研究院

神经科学通报(英文版)

CSTPCDCSCD

影响因子：0.741

ISSN：1673-7067

年,卷(期)：2023.39(11)

参考文献量81