Abstract
Parvalbumin interneurons belong to the major types of GABAergic interneurons.Although the distribu-tion and pathological alterations of parvalbumin interneu-ron somata have been widely studied,the distribution and vulnerability of the neurites and fibers extending from par-valbumin interneurons have not been detailly interrogated.Through the Cre recombinase-reporter system,we visual-ized parvalbumin-positive fibers and thoroughly investigated their spatial distribution in the mouse brain.We found that parvalbumin fibers are widely distributed in the brain with specific morphological characteristics in different regions,among which the cortex and thalamus exhibited the most intense parvalbumin signals.In regions such as the stria-tum and optic tract,even long-range thick parvalbumin pro-jections were detected.Furthermore,in mouse models of temporal lobe epilepsy and Parkinson's disease,parvalbu-min fibers suffered both massive and subtle morphological alterations.Our study provides an overview of parvalbumin fibers in the brain and emphasizes the potential pathological implications of parvalbumin fiber alterations.
基金项目
Ministry of science and Technology of China(2021ZD0201005)
National Natural Science Foundation of China(82071529)
National Natural Science Foundation of China(81974204)
Key R&D Program of Shaanxi Province(2021SF-238)
万方数据