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Advances and Applications of Brain Organoids

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Understanding the fundamental processes of human brain development and diseases is of great impor-tance for our health.However,existing research models such as non-human primate and mouse models remain limited due to their developmental discrepancies compared with humans.Over the past years,an emerging model,the"brain organoid"integrated from human pluripotent stem cells,has been developed to mimic developmental processes of the human brain and disease-associated phenotypes to some extent,making it possible to better understand the complex structures and functions of the human brain.In this review,we summarize recent advances in brain organoid technolo-gies and their applications in brain development and dis-eases,including neurodevelopmental,neurodegenerative,psychiatric diseases,and brain tumors.Finally,we also dis-cuss current limitations and the potential of brain organoids.

Human pluripotent stem cellBrain organoidBrain developmentNeurological disease

Yang Li、Peng-Ming Zeng、Jian Wu、Zhen-Ge Luo

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School of Life Science and Technology,ShanghaiTech University,Shanghai 201210,China

National Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaSTI2030-Major ProjectsFrontier Key Project of the Chinese Academy of SciencesShanghai Municipal Science and Technology ProjectsShanghai Frontiers Science Center for Biomacromolecules and Precision Medicine at ShanghaiTech University

32130035921681072021ZD0202500QYZDJ-SSW-SMC0252018SHZDZX05

2023

10.1007/s12264-023-01065-2

神经科学通报(英文版)
中国科学院上海生命科学研究院

神经科学通报(英文版)

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影响因子：0.741
ISSN：1673-7067
年,卷(期)：2023.39(11)
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