Neural Integration of Audiovisual Sensory Inputs in Macaque Amygdala and Adjacent Regions

Liang Shan ¹Liu Yuan ²Bo Zhang ³Jian Ma ⁴Xiao Xu ⁴Fei Gu ⁵Yi Jiang ⁶Ji Dai⁷

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作者信息

1. CAS Key Laboratory of Brain Connectome and Manipulation,the Brain Cognition and Brain Disease Institute(BCBDI),Shenzhen Institute of Advanced Technology,Chinese Academy of Sciences,Shenzhen 518055,China;Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research Institutions,Shenzhen 518055,China
2. CAS Key Laboratory of Brain Connectome and Manipulation,the Brain Cognition and Brain Disease Institute(BCBDI),Shenzhen Institute of Advanced Technology,Chinese Academy of Sciences,Shenzhen 518055,China;University of Chinese Academy of Sciences,Beijing 100049,China
3. CAS Key Laboratory of Brain Connectome and Manipulation,the Brain Cognition and Brain Disease Institute(BCBDI),Shenzhen Institute of Advanced Technology,Chinese Academy of Sciences,Shenzhen 518055,China;Key Laboratory of Brain Science,Zunyi Medical University,Zunyi 563000,China
4. CAS Key Laboratory of Brain Connectome and Manipulation,the Brain Cognition and Brain Disease Institute(BCBDI),Shenzhen Institute of Advanced Technology,Chinese Academy of Sciences,Shenzhen 518055,China
5. University of Chinese Academy of Sciences,Beijing 100049,China;State Key Laboratory of Brain and Cognitive Science,CAS Center for Excellence in Brain Science and Intelligence Technology,Institute of Psychology,Chinese Academy of Sciences,Beijing 100101,China
6. University of Chinese Academy of Sciences,Beijing 100049,China;State Key Laboratory of Brain and Cognitive Science,CAS Center for Excellence in Brain Science and Intelligence Technology,Institute of Psychology,Chinese Academy of Sciences,Beijing 100101,China;Chinese Institute for Brain Research,Beijing 102206,China
7. CAS Key Laboratory of Brain Connectome and Manipulation,the Brain Cognition and Brain Disease Institute(BCBDI),Shenzhen Institute of Advanced Technology,Chinese Academy of Sciences,Shenzhen 518055,China;Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research Institutions,Shenzhen 518055,China;University of Chinese Academy of Sciences,Beijing 100049,China;Shenzhen Technological Research Center for Primate Translational Medicine,Shenzhen 518055,China
折叠

Abstract

Integrating multisensory inputs to generate accurate perception and guide behavior is among the most critical functions of the brain.Subcortical regions such as the amygdala are involved in sensory processing including vision and audition,yet their roles in multisensory integra-tion remain unclear.In this study,we systematically investi-gated the function of neurons in the amygdala and adjacent regions in integrating audiovisual sensory inputs using a semi-chronic multi-electrode array and multiple combina-tions of audiovisual stimuli.From a sample of 332 neurons,we showed the diverse response patterns to audiovisual stimuli and the neural characteristics of bimodal over uni-modal modulation,which could be classified into four types with differentiated regional origins.Using the hierarchical clustering method,neurons were further clustered into five groups and associated with different integrating functions and sub-regions.Finally,regions distinguishing congruent and incongruent bimodal sensory inputs were identified.Overall,visual processing dominates audiovisual integration in the amygdala and adjacent regions.Our findings shed new light on the neural mechanisms of multisensory integration in the primate brain.

Key words

Macaque/Amygdala/Multisensory/Audiovisual integration/Neural activity/Multichannel recording

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基金项目

National Natural Science Foundation of China(U20A2017)

National Natural Science Foundation of China(31830037)

Guangdong Basic and Applied Basic Research Foundation(2020A1515010785)

Guangdong Basic and Applied Basic Research Foundation(2020A1515111118)

Guangdong Basic and Applied Basic Research Foundation(2022A1515010134)

Youth Innovation Promotion Association of the Chinese Academy of Sciences(2017120)

Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research Institutions(NYKFKT2019009)

Shenzhen Technological Research Center for Primate Translational Medicine(F-2021-Z99-504979)

Strategic Research Program of the Chinese Academy of Sciences(XDBS01030100)

Strategic Research Program of the Chinese Academy of Sciences(XDB32010300)

Scientific and Technological Innovation 2030(2021ZD0204300)

Fundamental Research Funds for the Central Universities()

出版年

2023

神经科学通报(英文版)

中国科学院上海生命科学研究院

神经科学通报(英文版)

CSTPCDCSCD

影响因子：0.741

ISSN：1673-7067

参考文献量52

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