首页|Neural Integration of Audiovisual Sensory Inputs in Macaque Amygdala and Adjacent Regions

Neural Integration of Audiovisual Sensory Inputs in Macaque Amygdala and Adjacent Regions

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Integrating multisensory inputs to generate accurate perception and guide behavior is among the most critical functions of the brain.Subcortical regions such as the amygdala are involved in sensory processing including vision and audition,yet their roles in multisensory integra-tion remain unclear.In this study,we systematically investi-gated the function of neurons in the amygdala and adjacent regions in integrating audiovisual sensory inputs using a semi-chronic multi-electrode array and multiple combina-tions of audiovisual stimuli.From a sample of 332 neurons,we showed the diverse response patterns to audiovisual stimuli and the neural characteristics of bimodal over uni-modal modulation,which could be classified into four types with differentiated regional origins.Using the hierarchical clustering method,neurons were further clustered into five groups and associated with different integrating functions and sub-regions.Finally,regions distinguishing congruent and incongruent bimodal sensory inputs were identified.Overall,visual processing dominates audiovisual integration in the amygdala and adjacent regions.Our findings shed new light on the neural mechanisms of multisensory integration in the primate brain.

MacaqueAmygdalaMultisensoryAudiovisual integrationNeural activityMultichannel recording

Liang Shan、Liu Yuan、Bo Zhang、Jian Ma、Xiao Xu、Fei Gu、Yi Jiang、Ji Dai

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CAS Key Laboratory of Brain Connectome and Manipulation,the Brain Cognition and Brain Disease Institute(BCBDI),Shenzhen Institute of Advanced Technology,Chinese Academy of Sciences,Shenzhen 518055,China

Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research Institutions,Shenzhen 518055,China

University of Chinese Academy of Sciences,Beijing 100049,China

Key Laboratory of Brain Science,Zunyi Medical University,Zunyi 563000,China

State Key Laboratory of Brain and Cognitive Science,CAS Center for Excellence in Brain Science and Intelligence Technology,Institute of Psychology,Chinese Academy of Sciences,Beijing 100101,China

Chinese Institute for Brain Research,Beijing 102206,China

Shenzhen Technological Research Center for Primate Translational Medicine,Shenzhen 518055,China

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National Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaGuangdong Basic and Applied Basic Research FoundationGuangdong Basic and Applied Basic Research FoundationGuangdong Basic and Applied Basic Research FoundationYouth Innovation Promotion Association of the Chinese Academy of SciencesShenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research InstitutionsShenzhen Technological Research Center for Primate Translational MedicineStrategic Research Program of the Chinese Academy of SciencesStrategic Research Program of the Chinese Academy of SciencesScientific and Technological Innovation 2030Fundamental Research Funds for the Central Universities

U20A2017318300372020A15150107852020A15151111182022A15150101342017120NYKFKT2019009F-2021-Z99-504979XDBS01030100XDB320103002021ZD0204300

2023

10.1007/s12264-023-01043-8

神经科学通报(英文版)
中国科学院上海生命科学研究院

神经科学通报(英文版)

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影响因子：0.741
ISSN：1673-7067
年,卷(期)：2023.39(12)
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