Abstract
Audiovisual integration is a vital information process involved in cognition and is closely correlated with aging and Alzheimer's disease(AD).In this review,we eval-uated the altered audiovisual integrative behavioral symp-toms in AD.We further analyzed the relationships between AD pathologies and audiovisual integration alterations bidirectionally and suggested the possible mechanisms of audiovisual integration alterations underlying AD,including the imbalance between energy demand and supply,activity-dependent degeneration,disrupted brain networks,and cog-nitive resource overloading.Then,based on the clinical char-acteristics including electrophysiological and imaging data related to audiovisual integration,we emphasized the value of audiovisual integration alterations as potential biomark-ers for the early diagnosis and progression of AD.We also highlighted that treatments targeted audiovisual integration contributed to widespread pathological improvements in AD animal models and cognitive improvements in AD patients.Moreover,investigation into audiovisual integration altera-tions in AD also provided new insights and comprehension about sensory information processes.
基金项目
National Key Research and Development Program of China(2022YFC3602600)
National Natural Science Foundation of China(82220108009)
National Natural Science Foundation of China(81970996)
STI2030-Major Projects(2021ZD0201801)
万方数据