Alterations of Audiovisual Integration in Alzheimer's Disease

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外文摘要：Audiovisual integration is a vital information process involved in cognition and is closely correlated with aging and Alzheimer's disease(AD).In this review,we eval-uated the altered audiovisual integrative behavioral symp-toms in AD.We further analyzed the relationships between AD pathologies and audiovisual integration alterations bidirectionally and suggested the possible mechanisms of audiovisual integration alterations underlying AD,including the imbalance between energy demand and supply,activity-dependent degeneration,disrupted brain networks,and cog-nitive resource overloading.Then,based on the clinical char-acteristics including electrophysiological and imaging data related to audiovisual integration,we emphasized the value of audiovisual integration alterations as potential biomark-ers for the early diagnosis and progression of AD.We also highlighted that treatments targeted audiovisual integration contributed to widespread pathological improvements in AD animal models and cognitive improvements in AD patients.Moreover,investigation into audiovisual integration altera-tions in AD also provided new insights and comprehension about sensory information processes.

外文关键词：

Audiovisual integrationAgingAlzheimer's diseaseCognitionSensory information process

作者：

Yufei Liu、Zhibin Wang、Tao Wei、Shaojiong Zhou、Yunsi Yin、Yingxin Mi、Xiaoduo Liu、Yi Tang

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作者单位：

Department of Neurology and Innovation Center for Neurological Disorders,Xuanwu Hospital,Capital Medical University,National Center for Neurological Disorders,Beijing 100053,China

基金：

National Key Research and Development Program of ChinaNational Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaSTI2030-Major Projects

项目编号：

2022YFC360260082220108009819709962021ZD0201801

出版年：

2023

DOI：

10.1007/s12264-023-01125-7

神经科学通报(英文版)

中国科学院上海生命科学研究院

神经科学通报(英文版)

CSTPCDCSCD

影响因子：0.741

ISSN：1673-7067

年,卷(期)：2023.39(12)

参考文献量166