首页|Neurocognitive Dysfunction After Treatment for Pediatric Brain Tumors:Subtype-Specific Findings and Proposal for Brain Network-Informed Evaluations

Neurocognitive Dysfunction After Treatment for Pediatric Brain Tumors:Subtype-Specific Findings and Proposal for Brain Network-Informed Evaluations

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The increasing number of long-term survivors of pediatric brain tumors requires us to incorporate the most recent knowledge derived from cognitive neuroscience into their oncological treatment.As the lesion itself,as well as each treatment,can cause specific neural damage,the long-term neurocognitive outcomes are highly complex and chal-lenging to assess.The number of neurocognitive studies in this population grows exponentially worldwide,motivat-ing modern neuroscience to provide guidance in follow-up before,during and after treatment.In this review,we provide an overview of structural and functional brain connectomes and their role in the neuropsychological outcomes of specific brain tumor types.Based on this information,we propose a theoretical neuroscientific framework to apply appropriate neuropsychological and imaging follow-up for future clinical care and rehabilitation trials.

ConnectomePediatric brain tumorNeuroimagingNeurocognitionNeuropsychological assessment

Charlotte Sleurs、Paul Fletcher、Conor Mallucci、Shivaram Avula、Thankamma Ajithkumar

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Department of Cognitive Neuropsychology,Tilburg University,5037 AB Tilburg,The Netherlands

Department of Oncology,KU Leuven,3000 Leuven,Belgium

Department of Psychiatry,University of Cambridge,Addenbrookes Hospital,Cambridge CB2 0QQ,UK

Wellcome Trust MRC Institute of Metabolic Science,University of Cambridge,Cambridge Biomedical Campus,Cambridge CB2 0QQ,UK

Department of Neurosurgery,Alder Hey Children's NHS Foundation Trust,Liverpool L14 5AB,UK

Department of Radiology,Alder Hey Children's NHS Foundation Trust,Liverpool L14 5AB,UK

Department of Oncology,Cambridge University Hospital NHS Trust,Cambridge CB2 0QQ,UK

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Fonds voor Wetenschappelijk Onderzoek for a senior postdoctoral fellowshipBernard Wolfe Health Neuroscience FundNIHR Cambridge Biomedical Research Centre

206368/Z/17/ZBRC-1215-20014

2023

10.1007/s12264-023-01096-9

神经科学通报(英文版)
中国科学院上海生命科学研究院

神经科学通报(英文版)

CSTPCDCSCD
影响因子：0.741
ISSN：1673-7067
年,卷(期)：2023.39(12)
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