首页|A ginkgo biloba extract promotes proliferation of endogenous neural stem cells in vascular dementia rats

A ginkgo biloba extract promotes proliferation of endogenous neural stem cells in vascular dementia rats

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  • 国家科技期刊平台
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The ginkgo biloba extract EGb761 improves memory loss and cognitive impairments in patients with senile dementia. It also promotes proliferation of neural stem cells in the subventricular zone in Parkinson's disease model mice and in the hippocampal zone of young epileptic rats. However, it remains unclear whether EGb761 enhances proliferation of endogenous neural stem cells in the brain of rats with vascular dementia. In this study, a vascular dementia model was established by repeatedly clipping and reperfusing the bilateral common carotid arteries of rats in combination with an intraperitoneal injection of a sodium nitroprusside solution. Seven days after establishing the model, rats were intragastrically given EGb761 at 50 mg/kg per day. Learning and memory abilities were assessed using the Morris water maze and proliferation of endogenous neural stem cells in the subventricular zone and dentate gyrus were labeled by 5-bromo-2-deoxyuridine immunofluorescence in all rats at 15 days, and 1, 2, and 4 months after model establishment. The escape latencies in Morris water maze tests of rats with vascular dementia after EGb761 treatment were significantly shorter than the model group. Immunofluorescence staining showed that the number and proliferation of 5-bromo-2-deoxyuridine-positive cells in the subventricular zone and dentate gyrus of the EGb761-treated group were significantly higher than in the model group. These experimental findings suggest that EGb761 enhances proliferation of neural stem cells in the subventricular zone and dentate gyrus, and significantly improves learning and memory in rats with vascular dementia.

neural regenerationtraditional Chinese medicineginkgo biloba extractEGb761vascular dementianeural stem cellssubventricular zonedentate gyruslearning and memorygrants-supported paperneuroregeneration

Jiwei Wang、Wen Chen、Yuliang Wang

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School of Medicine, Shandong University, Jinan 250012, Shandong Province, China

Department of Physiology, Weifang Medical University, Weifang 261042, Shandong Province, China

Natural Science Foundation of Shandong ProvinceScientific Research Funds of Shandong Provincial Education Ministry

Y2008C32J01K09

2013

10.3969/j.issn.1673-5374.2013.18.003

中国神经再生研究(英文版)
中国康复医学会

中国神经再生研究(英文版)

CSTPCDCSCDSCI
影响因子：0.902
ISSN：1673-5374
年,卷(期)：2013.8(18)
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