首页|Zhichan decoction induces differentiation of dopaminergic neurons in Parkinson’s disease rats after neural stem cell transplantation

Zhichan decoction induces differentiation of dopaminergic neurons in Parkinson’s disease rats after neural stem cell transplantation

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  • 国家科技期刊平台
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The goal of this study was to increase the dopamine content and reduce dopaminergic metab-olites in the brain of Parkinson’s disease rats. Using high-performance liquid chromatography, we found that dopamine and dopaminergic metabolite (dihydroxyphenylacetic acid and homo-vanillic acid) content in the midbrain of Parkinson’s disease rats was increased after neural stem cell transplantation + Zhichan decoction, compared with neural stem cell transplantation alone. Our genetic algorithm results show that dihydroxyphenylacetic acid and homovanillic acid levels achieve global optimization. Neural stem cell transplantation + Zhichan decoction increased dihydroxyphenylacetic acid levels up to 10-fold, while transplantation alone resulted in a 3-fold increment. Homovanillic acid levels showed no apparent change. Our experimental findings show that after neural stem cell transplantation in Parkinson’s disease rats, Zhichan decoction can promote differentiation of neural stem cells into dopaminergic neurons.

nerve regenerationtraditional Chinese medicineneurodegenerationParkinson’s diseaserat modelZhichan decoctionstem cell transplantationdopamine metabolitedihydroxy-phenylacetic acidhomovanillic acidcurve fitting equationgenetic algorithmoptimiza

Huifen Shi、Jie Song、Xuming Yang

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Department of Neurology, Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai, China

Department of Encephalopathy, Liu’an Hospital of Traditional Chinese Medicine, Liu’an, Anhui Province, China

College of Acupuncture and Massage, Shanghai University of Traditional Chinese Medicine, Shanghai, China

This study was financially supported by the National Natural Science Foundation of China

30772870

2014

10.4103/1673-5374.133135

中国神经再生研究(英文版)
中国康复医学会

中国神经再生研究(英文版)

CSTPCDCSCDSCI
影响因子：0.902
ISSN：1673-5374
年,卷(期)：2014.(9)
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