首页|Cortical regulation of striatal projection neurons and interneurons in a Parkinson's disease rat model

Cortical regulation of striatal projection neurons and interneurons in a Parkinson's disease rat model

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  • 国家科技期刊平台
  • NETL
  • NSTL
  • 万方数据
  • 维普
Striatal neurons can be either projection neurons or interneurons,with each type exhibiting distinct susceptibility to various types of brain damage.In this study,6-hydroxydopamine was injected into the right medial forebrain bundle to induce dopamine depletion,and/or ibotenic acid was injected into the M1 cortex to induce motor cortex lesions.Immunohistochemistry and western blot assay showed that dopaminergic depletion results in significant loss of striatal projection neurons marked by dopamine-and cyclic adenosine monophosphate-regulated phosphoprotein,molecular weight 32 kDa,calbindin,and μ-opioid receptor,while cortical lesions reversed these pathological changes.After dopaminergic deletion,the number of neuropeptide Y-positive striatal interneurons markedly increased,which was also inhibited by cortical lesioning.No noticeable change in the number of parvalbumin-positive interneurons was found in 6-hydroxydopamine-treated rats.Striatal projection neurons and interneurons show different susceptibility to dopaminergic depletion.Further,cortical lesions inhibit striatal dysfunction and damage induced by 6-hydroxydopamine,which provides a new possibility for clinical treatment of Parkinson's disease.

nerve regenerationmotor cortex lesionsdopaminergic neuronsGABAergic neuronsDarpp32calbindinμ-opioid receptorneuropeptide Yparvalbuminneural regeneration

Jia-jia Wu、Si Chen、Li-si Ouyang、Yu Jia、Bing-bing Liu、Shu-hua Mu、Yu-xin Ma

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Department of Anatomy, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, Guangdong Province, China

Periodical Center, the Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong Province, China

Department of Anesthesiology, Guangdong No.2 Provincial People's Hospital, Guangdong Provincial Emergency Hospital, Guangzhou,Guangdong Province, China

Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province, College of Optoelectronic Engineering, Shenzhen University, Shenzhen, Guangdong Province, China

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National Natural Science Foundation of China

81471288

2016

10.4103/1673-5374.197140

中国神经再生研究(英文版)
中国康复医学会

中国神经再生研究(英文版)

CSTPCDCSCDSCI
影响因子：0.902
ISSN：1673-5374
年,卷(期)：2016.11(12)
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