Netrin-1 signaling pathway mechanisms in neurodegenerative diseases

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外文摘要：Netrin-1 and its receptors play crucial roles in inducing axonal growth and neuronal migration during neuronal development.Their profound impacts then extend into adulthood to encompass the maintenance of neuronal survival and synaptic function.Increasing amounts of evidence highlight several key points:(1)Diminished Netrin-1 levels exacerbate pathological progression in animal models of Alzheimer's disease and Parkinson's disease,and potentially,similar alterations occur in humans.(2)Genetic mutations of Netrin-1 receptors increase an individuals'susceptibility to neurodegenerative disorders.(3)Therapeutic approaches targeting Netrin-1 and its receptors offer the benefits of enhancing memory and motor function.(4)Netrin-1 and its receptors show genetic and epigenetic alterations in a variety of cancers.These findings provide compelling evidence that Netrin-1 and its receptors are crucial targets in neurodegenerative diseases.Through a comprehensive review of Netrin-1 signaling pathways,our objective is to uncover potential therapeutic avenues for neurodegenerative disorders.

外文关键词：

Alzheimer's diseaseaxon guidancecolorectal cancerNetrin-1 receptorsNetrin-1 signaling pathwaysNetrin-1neurodegenerative diseasesneuron survivalParkinson's diseaseUNC5C

作者：

Kedong Zhu、Hualong Wang、Keqiang Ye、Guiqin Chen、Zhaohui Zhang

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作者单位：

Department of Neurology,Renmin Hospital of Wuhan University,Wuhan,Hubei Province,China

Department of Neurology,The First Hospita1 of Hebei Medical University

Brain Aging and Cognitive Neuroscience Laboratory of Heibei Province,Shijiazhuang,Hebei Province,China

Faculty of Life and Health Sciences,Shenzhen Institutes of Advanced Technology,Chinese Academy of Sciences,Shenzhen,Guangdong Province,China

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出版年：

2025

DOI：