首页|Cortico-striatal gamma oscillations are modulated by dopamine D3 receptors in dyskinetic rats
Cortico-striatal gamma oscillations are modulated by dopamine D3 receptors in dyskinetic rats
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Long-term levodopa administration can lead to the development of levodopa-induced dyskinesia.Gamma oscillations are a widely recognized hallmark of abnormal neural electrical activity in levodopa-induced dyskinesia.Currently,studies have reported increased oscillation power in cases of levodopa-induced dyskinesia.However,little is known about how the other electrophysiological parameters of gamma oscillations are altered in levodopa-induced dyskinesia.Furthermore,the role of the dopamine D3 receptor,which is implicated in levodopa-induced dyskinesia,in movement disorder-related changes in neural oscillations is unclear.We found that the cortico-striatal functional connectivity of beta oscillations was enhanced in a model of Parkinson's disease.Furthermore,levodopa application enhanced cortical gamma oscillations in cortico-striatal projections and cortical gamma aperiodic components,as well as bidirectional primary motor cortex(M1)↔ dorsolateral striatum gamma flow.Administration of PD128907(a selective dopamine D3 receptor agonist)induced dyskinesia and excessive gamma oscillations with a bidirectional M1 ↔ dorsolateral striatum flow.However,administration of PG01037(a selective dopamine D3 receptor antagonist)attenuated dyskinesia,suppressed gamma oscillations and cortical gamma aperiodic components,and decreased gamma causality in the M1 → dorsolateral striatum direction.These findings suggest that the dopamine D3 receptor plays a role in dyskinesia-related oscillatory activity,and that it has potential as a therapeutic target for levodopa-induced dyskinesia.
aperiodic componentsdopamine D3 receptordorsolateral striatumfunctional connectivitygamma oscillationslevodopa-induced-dyskinesialocal field potentialsneuromodulationParkinson's diseaseprimary motor cortex
Neurosurgery Center,Department of Pediatric Neurosurgery,Guangdong Provincial Key Laboratory on Brain Function Repair and Regeneration,Zhujiang Hospital,Southern Medical University,Guangzhou,Guangdong Province,China
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