Exercise preconditioning alleviates ischemia-induced memory deficits by increasing circulating adiponectin

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外文摘要：Cerebral ischemia is a major health risk that requires preventive approaches in addition to drug therapy.Physical exercise enhances neurogenesis and synaptogenesis,and has been widely used for functional rehabilitation after stroke.In this study,we determined whether exercise training before disease onset can alleviate the severity of cerebral ischemia.We also examined the role of exercise-induced circulating factors in these effects.Adult mice were subjected to 14 days of treadmill exercise training before surgery for middle cerebral artery occlusion.We found that this exercise pre-conditioning strategy effectively attenuated brain infarct area,inhibited gliogenesis,protected synaptic proteins,and improved novel object and spatial memory function.Further analysis showed that circulating adiponectin plays a critical role in these preventive effects of exercise.Agonist activation of adiponectin receptors by AdipoRon mimicked the effects of exercise,while inhibiting receptor activation abolished the exercise effects.In summary,our results suggest a crucial role of circulating adiponectin in the effects of exercise pre-conditioning in protecting against cerebral ischemia and supporting the health benefits of exercise.

外文关键词：

adiponectincerebral ischemiaexercise pre-conditioninghippocampusmemory functionmiddle cerebral artery occlusionprefrontal cortexsynaptic proteinstreadmill exercise

作者：

Meifeng Zheng、Borui Zhang、Sonata S Y Yau、Kwok-Fai So、Li Zhang、Haining Ou

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作者单位：

Department of Rehabilitation Medicine,Guangzhou Medical University,Guangzhou,Guangdong Province,China

Department of Rehabilitation Medicine,The Fifth Clinical College of Guangzhou Medical University,Guangzhou,Guangdong Province,China

Key Laboratory of CNS Regeneration(Ministry of Education),Guangdong-Hong Kong-Macau Institute of CNS Regeneration,Jinan University,Guangzhou,Guangdong Province,China

Department of Rehabilitation Sciences,The Hong Kong Polytechnic University,Hong Kong Special Administrative Region,China

State Key Laboratory of Brain and Cognitive Science,Li Ka Shing Faculty of Medicine,The University of Hong Kong,Hong Kong Special Administrative Region,China

Center for Exercise and Brain Science,School of Psychology,Shanghai University of Sport,Shanghai,China

Neuroscience and Neurorehabilitation Institute,University of Health and Rehabilitatio

Neuroscience and Neurorehabilitation Institute,University of Health and Rehabilitation Sciences,Qingdao,Shandong Province,China

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出版年：

2025

DOI：

10.4103/NRR.NRR-D-23-01101

中国神经再生研究(英文版)

中国康复医学会

中国神经再生研究(英文版)

影响因子：0.902

ISSN：1673-5374

年,卷(期)：2025.20(5)