Resting-state brain network remodeling after different nerve reconstruction surgeries:a functional magnetic resonance imaging study in brachial plexus injury rats

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外文摘要：Distinct brain remodeling has been found after different nerve reconstruction strategies,including motor representation of the affected limb.However,differences among reconstruction strategies at the brain network level have not been elucidated.This study aimed to explore intra-network changes related to altered peripheral neural pathways after different nerve reconstruction surgeries,including nerve repair,end-to-end nerve transfer,and end-to-side nerve transfer.Sprague-Dawley rats underwent complete left brachial plexus transection and were divided into four equal groups of eight:no nerve repair,grafted nerve repair,phrenic nerve end-to-end transfer,and end-to-side transfer with a graft sutured to the anterior upper trunk.Resting-state brain functional magnetic resonance imaging was obtained 7 months after surgery.The independent component analysis algorithm was utilized to identify group-level network components of interest and extract resting-state functional connectivity values of each voxel within the component.Alterations in intra-network resting-state functional connectivity were compared among the groups.Target muscle reinnervation was assessed by behavioral observation(elbow flexion)and electromyography.The results showed that alterations in the sensorimotor and interoception networks were mostly related to changes in the peripheral neural pathway.Nerve repair was related to enhanced connectivity within the sensorimotor network,while end-to-side nerve transfer might be more beneficial for restoring control over the affected limb by the original motor representation.The thalamic-cortical pathway was enhanced within the interoception network after nerve repair and end-to-end nerve transfer.Brain areas related to cognition and emotion were enhanced after end-to-side nerve transfer.Our study revealed important brain networks related to different nerve reconstructions.These networks may be potential targets for enhancing motor recovery.

外文关键词：

brain functional networksend-to-end nerve transferend-to-side nerve transferindependent component analysisnerve repairperipheral plexus injuryresting-state functional connectivity

作者：

Yunting Xiang、Xiangxin Xing、Xuyun Hua、Yuwen Zhang、Xin Xue、Jiajia Wu、Mouxiong Zheng、He Wang、Jianguang Xu

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作者单位：

School of Rehabilitation Science,Shanghai University of Traditional Chinese Medicine,Shanghai,China

Engineering Research Center of Traditional Chinese Medicine Intelligent Rehabilitation,Ministry of Education,Shanghai,China

Department of Rehabilitation Medicine,Yueyang Hospital of Integrated Traditional Chinese and Western Medicine,Shanghai University of Traditional Chinese Medicine,Shanghai,China

Department of Traumatology and Orthopedics,Yueyang Hospital of Integrated Traditional Chinese and Western Medicine,Shanghai University of Traditional Chinese Medicine,Shanghai,China

Institute of Science and Technology for Brain-Inspired Intelligence,Fudan University,Shanghai,China

Key Laboratory of Computational Neuroscience and Brain-Inspired Intelligence(Fudan University),Ministry of Education,Shanghai,China

Human Phenome Institute,Fudan University,Shanghai,China

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出版年：

2025

DOI：

10.4103/NRR.NRR-D-23-00493

中国神经再生研究(英文版)

中国康复医学会

中国神经再生研究(英文版)

影响因子：0.902

ISSN：1673-5374

年,卷(期)：2025.20(5)