首页|Peripheral mitochondrial DNA as a neuroinflammatory biomarker for major depressive disorder

Peripheral mitochondrial DNA as a neuroinflammatory biomarker for major depressive disorder

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In the pathogenesis of major depressive disorder,chronic stress-related neuroinflammation hinders favorable prognosis and antidepressant response.Mitochondrial DNA may be an inflammatory trigger,after its release from stress-induced dysfunctional central nervous system mitochondria into peripheral circulation.This evidence supports the potential use of peripheral mitochondrial DNA as a neuroinflammatory biomarker for the diagnosis and treatment of major depressive disorder.Herein,we critically review the neuroinflammation theory in major depressive disorder,providing compelling evidence that mitochondrial DNA release acts as a critical biological substrate,and that it constitutes the neuroinflammatory disease pathway.After its release,mitochondrial DNA can be carried in the exosomes and transported to extracellular spaces in the central nervous system and peripheral circulation.Detectable exosomes render encaged mitochondrial DNA relatively stable.This mitochondrial DNA in peripheral circulation can thus be directly detected in clinical practice.These characteristics illustrate the potential for mitochondrial DNA to serve as an innovative clinical biomarker and molecular treatment target for major depressive disorder.This review also highlights the future potential value of clinical applications combining mitochondrial DNA with a panel of other biomarkers,to improve diagnostic precision in major depressive disorder.

biomarkercytokineexosomesinflammasomemajor depressive disordermicrogliamitochondrial DNAmitochondrial dysfunctionneuroinflammationToll-like receptor

Jinmei Ye、Cong Duan、Jiaxin Han、Jinrong Chen、Ning Sun、Yuan Li、Tifei Yuan、Daihui Peng

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Division of Mood Disorder,Shanghai Mental Health Center,Shanghai Jiao Tong University School of Medicine,Shanghai,China

Department of Psychiatry,First Hospital of Shanxi Medical University,Taiyuan,Shanxi Province,China

Shanghai Key Laboratory of Psychotic Disorders,Brain Health Institute,National Center for Mental Disorders,Shanghai Mental Health Center,Shanghai Jiao Tong University School of Medicine,Shanghai,China

Co-Innovation Center of Neuroregeneration,Nantong University,Nantong,Jiangsu Province,China

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2025

10.4103/NRR.NRR-D-23-01878

中国神经再生研究(英文版)
中国康复医学会

中国神经再生研究(英文版)

影响因子：0.902
ISSN：1673-5374
年,卷(期)：2025.20(6)