首页|Therapeutic potential of exercise-hormone irisin in Alzheimer's disease
Therapeutic potential of exercise-hormone irisin in Alzheimer's disease
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Irisin is a myokine that is generated by cleavage of the membrane protein fibronectin typeⅢ domain-containing protein 5(FNDC5)in response to physical exercise.Studies reveal that irisin/FNDC5 has neuroprotective functions against Alzheimer's disease,the most common form of dementia in the elderly,by improving cognitive function and reducing amyloid-β and tau pathologies as well as neuroinflammation in cell culture or animal models of Alzheimer's disease.Although current and ongoing studies on irisin/FNDC5 show promising results,further mechanistic studies are required to clarify its potential as a meaningful therapeutic target for alleviating Alzheimer's disease.We recently found that irisin treatment reduces amyloid-β pathology by increasing the activity/levels of amyloid-β-degrading enzyme neprilysin secreted from astrocytes.Herein,we present an overview of irisin/FNDC5's protective roles and mechanisms against Alzheimer's disease.
Alzheimer's diseaseexercisefibronectin type Ⅲ domain-containing protein 5(FNDC5)irisin
Eunhee Kim、Rudolph E.Tanzi、Se Hoon Choi
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Genetics and Aging Research Unit,MassGeneral Institute for Neurodegenerative Disease,Department of Neurology,Massachusetts General Hospital,Harvard Medical School,Charlestown,MA,USA
McCance Center for Brain Health,Massachusetts General Hospital,Boston,MA,USA
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