The complex roles of m6A modifications in neural stem cell proliferation,differentiation,and self-renewal and implications for memory and neurodegenerative diseases

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外文摘要：N6-methyladenosine(m6A),the most prevalent and conserved RNA modification in eukaryotic cells,profoundly influences virtually all aspects of mRNA metabolism.mRNA plays crucial roles in neural stem cell genesis and neural regeneration,where it is highly concentrated and actively involved in these processes.Changes in m6A modification levels and the expression levels of related enzymatic proteins can lead to neurological dysfunction and contribute to the development of neurological diseases.Furthermore,the proliferation and differentiation of neural stem cells,as well as nerve regeneration,are intimately linked to memory function and neurodegenerative diseases.This paper presents a comprehensive review of the roles of m6A in neural stem cell proliferation,differentiation,and self-renewal,as well as its implications in memory and neurodegenerative diseases.m6A has demonstrated divergent effects on the proliferation and differentiation of neural stem cells.These observed contradictions may arise from the time-specific nature of m6A and its differential impact on neural stem cells across various stages of development.Similarly,the diverse effects of m6A on distinct types of memory could be attributed to the involvement of specific brain regions in memory formation and recall.Inconsistencies in m6A levels across different models of neurodegenerative disease,particularly Alzheimer's disease and Parkinson's disease,suggest that these disparities are linked to variations in the affected brain regions.Notably,the opposing changes in m6A levels observed in Parkinson's disease models exposed to manganese compared to normal Parkinson's disease models further underscore the complexity of m6A's role in neurodegenerative processes.The roles of m6A in neural stem cell proliferation,differentiation,and self-renewal,and its implications in memory and neurodegenerative diseases,appear contradictory.These inconsistencies may be attributed to the time-specific nature of m6A and its varying effects on distinct brain regions and in different environments.

外文关键词：

Alzheimer's diseasecell self-renewalcentral nervous systemmemorymicroglianerve regenerationneurodegenerative diseasesneurogenesisRNA methylation

作者：

Yanxi Li、Jing Xue、Yuejia Ma、Ke Ye、Xue Zhao、Fangliang Ge、Feifei Zheng、Lulu Liu、Xu Gao、Dayong Wang、Qing Xia

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作者单位：

Department of Biochemistry and Molecular Biology,College of Basic Medical Sciences,Harbin Medical University,Harbin,Heilongjiang Province,China

College of Basic Medical Sciences,Harbin Medical University,Harbin,Heilongjiang Province,China

Basic Medical Institute,Heilongjiang Academy of Medical Sciences,Harbin,Heilongjiang Province,China

Key Laboratory of Heilongjiang Province for Genetically Modified Animals,Harbin Medical University,Harbin,Heilongjiang Province,China

Translational Medicine Research and Coo

Translational Medicine Research and Cooperation Center of Northern China,Heilongjiang Academy of Medical Sciences,Harbin,Heilongjiang Province,China

Dongzhimen Hospital,Beijing University of Chinese Medicine,Beijing,China

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出版年：

2025

DOI：

10.4103/NRR.NRR-D-23-01872

中国神经再生研究(英文版)

中国康复医学会

中国神经再生研究(英文版)

影响因子：0.902

ISSN：1673-5374

年,卷(期)：2025.20(6)