首页|Inhibition of the cGAS-STING pathway:contributing to the treatment of cerebral ischemia-reperfusion injury

Inhibition of the cGAS-STING pathway:contributing to the treatment of cerebral ischemia-reperfusion injury

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The cGAS-STING pathway plays an important role in ischemia-reperfusion injury in the heart,liver,brain,and kidney,but its role and mechanisms in cerebral ischemia-reperfusion injury have not been systematically reviewed.Here,we outline the components of the cGAS-STING pathway and then analyze its role in autophagy,ferroptosis,cellular pyroptosis,disequilibrium of calcium homeostasis,inflammatory responses,disruption of the blood-brain barrier,microglia transformation,and complement system activation following cerebral ischemia-reperfusion injury.We further analyze the value of cGAS-STING pathway inhibitors in the treatment of cerebral ischemia-reperfusion injury and conclude that the pathway can regulate cerebral ischemia-reperfusion injury through multiple mechanisms.Inhibition of the cGAS-STING pathway may be helpful in the treatment of cerebral ischemia-reperfusion injury.

calcium homeostasiscellular autophagycerebral ischemia-reperfusion injurycGAS-STING pathwayferroptosisgut-brain-microbiota axisinflammatorylight chain 3microglial cellsSyntaxin-17 protein

Hang Yang、Yulei Xia、Yue Ma、Mingtong Gao、Shuai Hou、Shanshan Xu、Yanqiang Wang

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School of Clinical Medicine,Shandong Second Medical University,Weifang,Shandong Province,China

Department of Emergency,The Affiliated Hospital of Weifang Medical University,Weifang,Shandong Province,China

Department of Neurology Ⅱ,The Affiliated Hospital of Weifang Medical University,Weifang,Shandong Province,China

2025

中国神经再生研究(英文版)
中国康复医学会

中国神经再生研究(英文版)

影响因子:0.902
ISSN:1673-5374
年,卷(期):2025.20(7)