首页|A promising approach for quantifying focal stroke modeling and assessing stroke progression:optical resolution photoacoustic microscopy photothrombosis

A promising approach for quantifying focal stroke modeling and assessing stroke progression:optical resolution photoacoustic microscopy photothrombosis

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To investigate the mechanisms underlying the onset and progression of ischemic stroke,some methods have been proposed that can simultaneously monitor and create embolisms in the animal cerebral cortex.However,these methods often require complex systems and the effect of age on cerebral embolism has not been adequately studied,although ischemic stroke is strongly age-related.In this study,we propose an optical-resolution photoacoustic microscopy-based visualized photothrombosis methodology to create and monitor ischemic stroke in mice simultaneously using a 532 nm pulsed laser.We observed the molding process in mice of different ages and presented age-dependent vascular embolism differentiation.Moreover,we integrated optical coherence tomography angiography to investigate age-associated trends in cerebrovascular variability following a stroke.Our imaging data and quantitative analyses underscore the differential cerebrovascular responses to stroke in mice of different ages,thereby highlighting the technique's potential for evaluating cerebrovascular health and unraveling age-related mechanisms involved in ischemic strokes.

age-dependentcerebral cortexischemic strokemouse modeloptical coherence tomography angiographyphotoacoustic microscopyphotothrombosisvascular imaging

Xiao Liang、Xingping Quan、Xiaorui Geng、Yujing Huang、Yonghua Zhao、Lei Xi、Zhen Yuan、Ping Wang、Bin Liu

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Faculty of Health Sciences,University of Macau,Macao Special Administrative Region,China

Center for Cognitive and Brain Sciences,University of Macau,Macao Special Administrative Region,China

Department of Biomedical Engineering,Southern University of Science and Technology,Shenzhen,Guangdong Province,China

State Key Laboratory of Quality Research in Chinese Medicine,Institute of Chinese Medical Sciences,University of Macau,Taipa,Macao Special Administrative Region,China

Department of Emergency,Zhujiang Hospital,Southern Medical University,Guangzhou,Guangdong Province,China

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2025

10.4103/NRR.NRR-D-23-01617

中国神经再生研究(英文版)
中国康复医学会

中国神经再生研究(英文版)

影响因子：0.902
ISSN：1673-5374
年,卷(期)：2025.20(7)