首页|A novel flexible nerve guidance conduit promotes nerve regeneration while providing excellent mechanical properties

A novel flexible nerve guidance conduit promotes nerve regeneration while providing excellent mechanical properties

扫码查看
原文链接
  • 万方数据
  • 维普
Autografting is the gold standard for surgical repair of nerve defects＞5 mm in length;however,autografting is associated with potential complications at the nerve donor site.As an alternative,nerve guidance conduits may be used.The ideal conduit should be flexible,resistant to kinks and lumen collapse,and provide physical cues to guide nerve regeneration.We designed a novel flexible conduit using electrospinning technology to create fibers on the innermost surface of the nerve guidance conduit and employed melt spinning to align them.Subsequently,we prepared disordered electrospun fibers outside the aligned fibers and helical melt-spun fibers on the outer wall of the electrospun fiber lumen.The presence of aligned fibers on the inner surface can promote the extension of nerve cells along the fibers.The helical melt-spun fibers on the outer surface can enhance resistance to kinking and compression and provide stability.Our novel conduit promoted nerve regeneration and functional recovery in a rat sciatic nerve defect model,suggesting that it has potential for clinical use in human nerve injuries.

aligned fibersanti-kinkinghelical fibersnerve guidance conduitnerve regenerationperipheral nerve injurytopological guidance

Tong Li、Quhan Cheng、Jingai Zhang、Boxin Liu、Yu Shi、Haoxue Wang、Lijie Huang、Su Zhang、Ruixin Zhang、Song Wang、Guangxu Lu、Peifu Tang、Zhongyang Liu、Kai Wang

展开 >

Department of Orthopedics,the Fourth Medical Center of Chinese PLA General Hospital,Beijing,China

Department of Training and Sports Medicine,Characteristic Medical Center of Chinese People's Armed Police Force,Tianjin,China

Medical School of Chinese PLA,Beijing,China

Key Laboratory of Bioactive Materials for the Ministry of Education,College of Life Sciences,Nankai University,Tianjin,China

Department of Orthopedics,Tianjin Hospital,Tianjin,China

Department of Rehabilitation Medicine,Er Quan Hospital of PAP,Wuxi,Jiangsu Province,China

展开 >

2025

10.4103/NRR.NRR-D-23-01792

中国神经再生研究(英文版)
中国康复医学会

中国神经再生研究(英文版)

影响因子：0.902
ISSN：1673-5374
年,卷(期)：2025.20(7)