首页|FK506 contributes to peripheral nerve regeneration by inhibiting neuroinflammatory responses and promoting neuron survival

FK506 contributes to peripheral nerve regeneration by inhibiting neuroinflammatory responses and promoting neuron survival

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FK506(Tacrolimus)is a systemic immunosuppressant approved by the U.S.Food and Drug Administration.FK506 has been shown to promote peripheral nerve regeneration,however,its precise mechanism of action and its pathways remain unclear.In this study,we established a rat model of sciatic nerve injury and found that FK506 improved the morphology of the injured sciatic nerve,increased the numbers of motor and sensory neurons,reduced inflammatory responses,markedly improved the conduction function of the injured nerve,and promoted motor function recovery.These findings suggest that FK506 promotes peripheral nerve structure recovery and functional regeneration by reducing the intensity of inflammation after neuronal injury and increasing the number of surviving neurons.

FK506inflammationmotor neuronsnerve regenerationneuronperipheral nerve injurysensory neurons

Yuhui Kou、Zongxue Jin、Yusong Yuan、Bo Ma、Wenyong Xie、Na Han

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Department of Trauma and Orthopedics,Peking University People's Hospital,Beijing,China

National Center for Trauma Medicine,Peking University People's Hospital,Beijing,China

Key Laboratory of Trauma and Neural Regeneration(Peking University),Ministry of Education,Beijing,China

Trauma Medicine Center,Peking University People's Hospital,Beijing,China

Department of Orthopedics,China-Japan Friendship Hospital,Beijing,China

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2025

10.4103/NRR.NRR-D-22-00867

中国神经再生研究(英文版)
中国康复医学会

中国神经再生研究(英文版)

影响因子：0.902
ISSN：1673-5374
年,卷(期)：2025.20(7)