Utilizing engineered extracellular vesicles as delivery vectors in the management of ischemic stroke:a special outlook on mitochondrial delivery

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外文摘要：Ischemic stroke is a secondary cause of mortality worldwide,imposing considerable medical and economic burdens on society.Extracellular vesicles,serving as natural nano-carriers for drug delivery,exhibit excellent biocompatibility in vivo and have significant advantages in the management of ischemic stroke.However,the uncertain distribution and rapid clearance of extracellular vesicles impede their delivery efficiency.By utilizing membrane decoration or by encapsulating therapeutic cargo within extracellular vesicles,their delivery efficacy may be greatly improved.Furthermore,previous studies have indicated that microvesicles,a subset of large-sized extracellular vesicles,can transport mitochondria to neighboring cells,thereby aiding in the restoration of mitochondrial function post-ischemic stroke.Small extracellular vesicles have also demonstrated the capability to transfer mitochondrial components,such as proteins or deoxyribonucleic acid,or their sub-components,for extracellular vesicle-based ischemic stroke therapy.In this review,we undertake a comparative analysis of the isolation techniques employed for extracellular vesicles and present an overview of the current dominant extracellular vesicle modification methodologies.Given the complex facets of treating ischemic stroke,we also delineate various extracellular vesicle modification approaches which are suited to different facets of the treatment process.Moreover,given the burgeoning interest in mitochondrial delivery,we delved into the feasibility and existing research findings on the transportation of mitochondrial fractions or intact mitochondria through small extracellular vesicles and microvesicles to offer a fresh perspective on ischemic stroke therapy.

外文关键词：

deliveryengineeringextracellular vesiclesidentificationischemic strokeisolationmitochondriatargeting strategytherapeutic effects

作者：

Jiali Chen、Yiyang Li、Xingping Quan、Jinfen Chen、Yan Han、Li Yang、Manfei Zhou、Greta Seng Peng Mok、Ruibing Wang、Yonghua Zhao

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作者单位：

Institute of Chinese Medical Sciences,State Key Laboratory of Quality Research in Chinese Medicine,University of Macau,Taipa,Macao Special Administrative Region,China

Department of Pharmacy,Hunan Provincial People's Hospital,the First Affiliated Hospital of Hunan Normal University,Changsha,Hunan Province,China

Department of Electrical and Computer Engineering,University of Macau,Taipa,Macao Special Administrative Region,China

Department of Pharmaceutical Sciences,Faculty of Health Sciences,University of Macau,Taipa,Macao Special Administrative Region,China

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出版年：

2025

DOI：

10.4103/NRR.NRR-D-24-00243

中国神经再生研究(英文版)

中国康复医学会

中国神经再生研究(英文版)

影响因子：0.902

ISSN：1673-5374

年,卷(期)：2025.20(8)