Decoding molecular mechanisms:brain aging and Alzheimer's disease

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外文摘要：The complex morphological,anatomical,physiological,and chemical mechanisms within the aging brain have been the hot topic of research for centuries.The aging process alters the brain structure that affects functions and cognitions,but the worsening of such processes contributes to the pathogenesis of neurodegenerative disorders,such as Alzheimer's disease.Beyond these observable,mild morphological shifts,significant functional modifications in neurotransmission and neuronal activity critically influence the aging brain.Understanding these changes is important for maintaining cognitive health,especially given the increasing prevalence of age-related conditions that affect cognition.This review aims to explore the age-induced changes in brain plasticity and molecular processes,differentiating normal aging from the pathogenesis of Alzheimer's disease,thereby providing insights into predicting the risk of dementia,particularly Alzheimer's disease.

外文关键词：

Alzheimer's diseasebrain agingcognitive healthdementiamolecular mechanismsneuronal activityneuroplasticityneurotransmission

作者：

Mahnoor Hayat、Rafay Ali Syed、Hammad Qaiser、Mohammad Uzair、Khalid Al-Regaiey、Roaa Khallaf、Lubna Abdullah Mohammed Albassam、Imdad Kaleem、Xueyi Wang、Ran Wang、Mehwish S.Bhatti、Shahid Bashir

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作者单位：

Atta-ur-Rahman School of Applied Biosciences(ASAB),National University of Sciences and Technology(NUST),Islamabad,Pakistan

Department of Biotechnology,Quaid-i-Azam University,Islamabad,Pakistan

Department of Biological Sciences,Faculty of Basic & Applied Sciences,International Islamic University Islamabad(IIUI),Islamabad,Pakistan

Department of Bioengineering,King Fahd University of Petroleum and Minerals,Dhahran,Saudi Arabia

Department of Physiology,College of Medicine,King Saud University,Riyadh,Saudi Arabia

Department of Neurology,Neuroscience Center,King Fahad Specialist Hospital,Dammam,Saudi Arabia

Department of Mental Health,Neuroscience Center,King Fahad Specialist Hospital,Dammam,Saudi Arabia

Department of Biosciences,Commission on Science and Technology for Sustainable Development in the South(COMSATS University),Islamabad,Pakistan

Department of Psychiatry,The First Hospital of Hebei Medical University,Shijiazhuang,Hebei Province,China

Mental Health Institute of Hebei Medical University,Shijiazhuang,Hebei Province,China

Department of Neurobiology and Behavior,University of California,Irvine,CA,USA

Neuroscience Center,King Fahad Specialist Hospital Dammam,Dammam,Saudi Arabia

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出版年：

2025

DOI：

10.4103/NRR.NRR-D-23-01403

中国神经再生研究(英文版)

中国康复医学会

中国神经再生研究(英文版)

影响因子：0.902

ISSN：1673-5374

年,卷(期)：2025.20(8)