Nanocarrier-mediated siRNA delivery:a new approach for the treatment of traumatic brain injury-related Alzheimer's disease

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外文摘要：Traumatic brain injury and Alzheimer's disease share pathological similarities,including neuronal loss,amyloid-β deposition,tau hyperphosphorylation,blood-brain barrier dysfunction,neuroinflammation,and cognitive deficits.Furthermore,traumatic brain injury can exacerbate Alzheimer's disease-like pathologies,potentially leading to the development of Alzheimer's disease.Nanocarriers offer a potential solution by facilitating the delivery of small interfering RNAs across the blood-brain barrier for the targeted silencing of key pathological genes implicated in traumatic brain injury and Alzheimer's disease.Unlike traditional approaches to neuroregeneration,this is a molecular-targeted strategy,thus avoiding non-specific drug actions.This review focuses on the use of nanocarrier systems for the efficient and precise delivery of siRNAs,discussing the advantages,challenges,and future directions.In principle,siRNAs have the potential to target all genes and non-targetable proteins,holding significant promise for treating various diseases.Among the various therapeutic approaches currently available for neurological diseases,siRNA gene silencing can precisely"turn off"the expression of any gene at the genetic level,thus radically inhibiting disease progression;however,a significant challenge lies in delivering siRNAs across the blood-brain barrier.Nanoparticles have received increasing attention as an innovative drug delivery tool for the treatment of brain diseases.They are considered a potential therapeutic strategy with the advantages of being able to cross the blood-brain barrier,targeted drug delivery,enhanced drug stability,and multifunctional therapy.The use of nanoparticles to deliver specific modified siRNAs to the injured brain is gradually being recognized as a feasible and effective approach.Although this strategy is still in the preclinical exploration stage,it is expected to achieve clinical translation in the future,creating a new field of molecular targeted therapy and precision medicine for the treatment of Alzheimer's disease associated with traumatic brain injury.

外文关键词：

blood-brain barriercognitive dysfunctionexosomesgene silencingimmunotherapyinorganic nanomaterialsliposome nanoparticlesneuroinflammationpolymer nanoparticlesstem cells

作者：

Jie Jin、Huajing Zhang、Qianying Lu、Linqiang Tian、Sanqiao Yao、Feng Lai、Yangfan Liang、Chuanchuan Liu、Yujia Lu、Sijia Tian、Yanmei Zhao、Wenjie Ren

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作者单位：

Institute of Disaster and Emergency Medicine,Tianjin University,Tianjin,China

Key Laboratory for Disaster Medicine Technology,Tianjin,China

Henan Medical Key Laboratory for Research of Trauma and Orthopedics,The Third Affiliated Hospital of Xinxiang Medical University,Xinxiang,Henan Province,China

Clinical Medical Center of Tissue Engineering and Regeneration,Xinxiang Medical University,Xinxiang,Henan Province,China

Institutes of Health Central Plain,Xinxiang Medical University,Xinxiang,Henan Province,China

School of Public Health,Xinxiang Medical University,Xinxiang,Henan Province,China

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出版年：

2025

DOI：

10.4103/NRR.NRR-D-24-00303

中国神经再生研究(英文版)

中国康复医学会

中国神经再生研究(英文版)

影响因子：0.902

ISSN：1673-5374

年,卷(期)：2025.20(9)