Decreased levels of phosphorylated synuclein in plasma are correlated with poststroke cognitive impairment

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外文摘要：Poststroke cognitive impairment is a major secondary effect of ischemic stroke in many patients;however,few options are available for the early diagnosis and treatment of this condition.The aims of this study were to(1)determine the specific relationship between hypoxic andα-synuclein during the occur of poststroke cognitive impairment and(2)assess whether the serum phosphorylated α-synuclein level can be used as a biomarker for poststroke cognitive impairment.We found that the phosphorylated α-synuclein level was significantly increased and showed pathological aggregation around the cerebral infarct area in a mouse model of ischemic stroke.In addition,neuronal α-synuclein phosphorylation and aggregation were observed in the brain tissue of mice subjected to chronic hypoxia,suggesting that hypoxia is the underlying cause of α-synuclein-mediated pathology in the brains of mice with ischemic stroke.Serum phosphorylated α-synuclein levels in patients with ischemic stroke were significantly lower than those in healthy subjects,and were positively correlated with cognition levels in patients with ischemic stroke.Furthermore,a decrease in serum high-density lipoprotein levels in stroke patients was significantly correlated with a decrease in phosphorylated α-synuclein levels.Although ischemic stroke mice did not show significant cognitive impairment or disrupted lipid metabolism 14 days after injury,some of them exhibited decreased cognitive function and reduced phosphorylated α-synuclein levels.Taken together,our results suggest that serum phosphorylated α-synuclein is a potential biomarker for poststroke cognitive impairment.

外文关键词：

biomarkerhigh-density lipoproteinischemic strokephosphorylated α-synucleinpoststroke cognitive impairment

作者：

Yi Wang、Yuning Li、Yakun Gu、Wei Ma、Yuying Guan、Mengyuan Guo、Qianqian Shao、Xunming Ji、Jia Liu

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作者单位：

Department of Clinical Laboratory,Beijing Bo'ai Hospital,China Rehabilitation Research Center,Capital Medical University,Beijing,China

Beijing Institute of Brain Disorders,Laboratory of Brain Disorders,Ministry of Science and Technology,Collaborative Innovation Center for Brain Disorders,Beijing Advanced Innovation Center for Big Data-based Precision Medicine,Capital Medical University,Beijing,China

Department of Neurosurgery,Xuanwu Hospital,Capital Medical University,Beijing,China

出版年：

2025

DOI：

10.4103/NRR.NRR-D-23-01348

中国神经再生研究(英文版)

中国康复医学会

中国神经再生研究(英文版)

影响因子：0.902

ISSN：1673-5374

年,卷(期)：2025.20(9)