首页|PI3K/AKT signaling and neuroprotection in ischemic stroke:molecular mechanisms and therapeutic perspectives

PI3K/AKT signaling and neuroprotection in ischemic stroke:molecular mechanisms and therapeutic perspectives

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It has been reported that the PI3K/AKT signaling pathway plays a key role in the pathogenesis of ischemic stroke.As a result,the development of drugs targeting the PI3K/AKT signaling pathway has attracted increasing attention from researchers.This article reviews the pathological mechanisms and advancements in research related to the signaling pathways in ischemic stroke,with a focus on the PI3K/AKT signaling pathway.The key findings include the following:(1)The complex pathological mechanisms of ischemic stroke can be categorized into five major types:excitatory amino acid toxicity,Ca2+overload,inflammatory response,oxidative stress,and apoptosis.(2)The PI3K/AKT-mediated signaling pathway is closely associated with the occurrence and progression of ischemic stroke,which primarily involves the NF-κB,NRF2,BCL-2,mTOR,and endothelial NOS signaling pathways.(3)Natural products,including flavonoids,quinones,alkaloids,phenylpropanoids,phenols,terpenoids,and iridoids,show great potential as candidate substances for the development of innovative anti-stroke medications.(4)Recently,novel therapeutic techniques,such as electroacupuncture and mesenchymal stem cell therapy,have demonstrated the potential to improve stroke outcomes by activating the PI3K/AKT signaling pathway,providing new possibilities for the treatment and rehabilitation of patients with ischemic stroke.Future investigations should focus on the direct regulatory mechanisms of drugs targeting the PI3K/AKT signaling pathway and their clinical translation to develop innovative treatment strategies for ischemic stroke.

apoptosisautophagyinflammationischemic strokeneuroprotectionoxidative stresspathogenesisphosphatidylinositol 3-kinaseprotein kinase Btherapeutics

Tianlong Liu、Xiaolin Li、Xiaowei Zhou、Wei Chen、Aidong Wen、Minna Liu、Yi Ding

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Department of Pharmacy,Xijing Hospital,Fourth Military Medical University,Xi'an,Shaanxi Province,China

Department of Pharmacy,The 940 Hospital of Joint Logistics Support Forces of Chinese PLA,Lanzhou,Gansu Province,China

Department of Pharmacy,The 944 Hospital of Joint Logistics Support Forces of Chinese PLA,Jiuquan,Gansu Province,China

Department of Nephrology,The 940 Hospital of Joint Logistics Support Forces of Chinese PLA,Lanzhou,Gansu Province,China

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2025

10.4103/NRR.NRR-D-24-00568

中国神经再生研究(英文版)
中国康复医学会

中国神经再生研究(英文版)

影响因子：0.902
ISSN：1673-5374
年,卷(期)：2025.20(10)