Multilevel analysis of the central-peripheral-target organ pathway:contributing to recovery after peripheral nerve injury

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外文摘要：Peripheral nerve injury is a common neurological condition that often leads to severe functional limitations and disabilities.Research on the pathogenesis of peripheral nerve injury has focused on pathological changes at individual injury sites,neglecting multilevel pathological analysis of the overall nervous system and target organs.This has led to restrictions on current therapeutic approaches.In this paper,we first summarize the potential mechanisms of peripheral nerve injury from a holistic perspective,covering the central nervous system,peripheral nervous system,and target organs.After peripheral nerve injury,the cortical plasticity of the brain is altered due to damage to and regeneration of peripheral nerves;changes such as neuronal apoptosis and axonal demyelination occur in the spinal cord.The nerve will undergo axonal regeneration,activation of Schwann cells,inflammatory response,and vascular system regeneration at the injury site.Corresponding damage to target organs can occur,including skeletal muscle atrophy and sensory receptor disruption.We then provide a brief review of the research advances in therapeutic approaches to peripheral nerve injury.The main current treatments are conducted passively and include physical factor rehabilitation,pharmacological treatments,cell-based therapies,and physical exercise.However,most treatments only partially address the problem and cannot complete the systematic recovery of the entire central nervous system-peripheral nervous system-target organ pathway.Therefore,we should further explore multilevel treatment options that produce effective,long-lasting results,perhaps requiring a combination of passive(traditional)and active(novel)treatment methods to stimulate rehabilitation at the central-peripheral-target organ levels to achieve better functional recovery.

外文关键词：

central nervous systemcentral peripheral target organmultilevel pathological analysisnerve regenerationperipheral nerve injuryperipheral nervous systemtarget organstherapeutic approach

作者：

Xizi Song、Ruixin Li、Xiaolei Chu、Qi Li、Ruihua Li、Qingwen Li、Kai-Yu Tong、Xiaosong Gu、Dong Ming

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作者单位：

Academy of Medical Engineering and Translational Medicine,Tianjin University,Tianjin,China

Haihe Laboratory of Brain-Machine Interface and Human-Machine Fusion,Tianjin,China

Department of Rehabilitation,Tianjin University Tianjin Hospital,Tianjin,China

Department of Hand Microsurgery,Tianjin University Tianjin Hospital,Tianjin,China

School of Exercise and Health,Tianjin University of Sport,Tianjin,China

Department of Biomedical Engineering,the Chinese University of Hong Kong,Hong Kong Special Administrative Region,China

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出版年：

2025

DOI：

10.4103/NRR.NRR-D-24-00641

中国神经再生研究(英文版)

中国康复医学会

中国神经再生研究(英文版)

影响因子：0.902

ISSN：1673-5374

年,卷(期)：2025.20(10)